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- W2247293364 abstract "15100 Background: FOLFOX4 is one of the standard therapies for patients with metastatic colorectal cancer (mCRC) in Japan. Past clinical studies show the complete response (CR) rate was 4 percent. We had both highly chemo-sensitive patients who achieved CR and chemo-resistant patients who had progressive disease (PD), after FOLFOX4. By comparing both groups, we investigated the clinical pathological characteristics of patients after FOLFOX4 therapy. Methods: CR and PD patients were chosen retrospectively from 427 mCRC patients who underwent FOLFOX4 therapy in our single institute. Results: Twelve (3%) patients achieved CR, twenty (4.7%) had PD. Among CR patients, eleven had recurrent disease after colorectomy, nine had a single recurrent site. Median amount of tumor lesion prior to treatment was five, and the median size of largest measurable lesion was 20.0 mm. All PD patients had recurrent disease after colorectomy, nineteen with multiorgan recurrence, and the largest measurable tumor size was 41.0 mm. The median CEA prior to treatment was significantly lower in CR patients compared to PD patients, 9.9 ng/ml and 63.8 ng/ml. The median time to confirming CR was 6.7 months (range: 3–12 months), median number of treatment courses was 12 (range: 5–18), and all patients were given standard dose of FOLFOX4. All CR patients experienced at lowest Grade 1 (CTCAE v. 3.0) neuropathy. Treatment was discontinued in seven patients after confirming CR, among which five had recurrence, median time before recurrence was 3.5 months (range: 2.9–8.5 months). Of four patients where treatment has continued, no recurrence has been reported. Conclusions: Our study suggests that CEA level, tumor size, and number of recurrent site could be predictive factor of treatment effect. No significant financial relationships to disclose." @default.
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- W2247293364 date "2008-05-20" @default.
- W2247293364 modified "2023-09-27" @default.
- W2247293364 title "A retrospective analysis of patients with complete response (CR) after FOLFOX4: Single institute experience" @default.
- W2247293364 doi "https://doi.org/10.1200/jco.2008.26.15_suppl.15100" @default.
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