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- W2247294990 abstract "Publisher Summary The most fascinating aspect of transcriptomics is that the entire set of messenger RNA (mRNA) molecules or transcripts produced in a population of cells or in tissues can be analyzed simultaneously. The present microarray technology produces devices equivalent to the size of a stamp for gene expression profiling. Analyzing the transcriptome is a challenging task, since the mRNA content of a biological entity is heterogeneous and can vary substantially. The abundance of individual transcripts varies from a few copies to hundreds or thousands of copies per cell. The kinds and copy numbers of individual transcripts expressed at a given time depend on the developmental stage, on external conditions, and environmental stimuli. Quantitative and qualitative alterations of mRNAs can be directly linked to the molecular mechanism of disease or reflect the downstream consequences of these disease processes. This chapter outlines the methodological prerequisites for transcriptome analysis and describes typical applications in molecular cell biology and pathology." @default.
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- W2247294990 date "2009-01-01" @default.
- W2247294990 modified "2023-09-25" @default.
- W2247294990 title "The Human Transcriptome: Implications for the Understanding of Human Disease" @default.
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- W2247294990 doi "https://doi.org/10.1016/b978-0-12-374419-7.00007-x" @default.
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