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- W2247336727 abstract "Cell reprogramming is a process of transitions from differentiated to pluripotent cell states via transient intermediate states. Within the epigenetic landscape framework, such a process is regarded as a sequence of transitions among basins on the landscape; therefore, theoretical construction of a model landscape which exhibits experimentally consistent dynamics can provide clues to understanding epigenetic mechanism of reprogramming. We propose a minimal gene-network model of the landscape, in which each gene is regulated by an integrated mechanism of transcription-factor binding/unbinding and the collective chemical modification of histones. We show that the slow collective variation of many histones around each gene locus alters topology of the landscape and significantly affects transition dynamics between basins. Differentiation and reprogramming follow different transition pathways on the calculated landscape, which should be verified experimentally via single-cell pursuit of the reprogramming process. Effects of modulation in collective histone state kinetics on transition dynamics and pathway are examined in search for an efficient protocol of reprogramming." @default.
- W2247336727 created "2016-06-24" @default.
- W2247336727 creator A5016751632 @default.
- W2247336727 creator A5061908886 @default.
- W2247336727 date "2015-11-19" @default.
- W2247336727 modified "2023-10-01" @default.
- W2247336727 title "Effects of Collective Histone State Dynamics on Epigenetic Landscape and Kinetics of Cell Reprogramming" @default.
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- W2247336727 doi "https://doi.org/10.1038/srep16746" @default.
- W2247336727 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4652167" @default.
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- W2247336727 hasPublicationYear "2015" @default.
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