Matches in SemOpenAlex for { <https://semopenalex.org/work/W2247366218> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2247366218 endingPage "162" @default.
- W2247366218 startingPage "159" @default.
- W2247366218 abstract "In developing a drug delivery strategy, issues of absorption, distribution, metabolism, and elimination must be considered. The eye presents unique opportunities and challenges when it comes to the delivery of pharmaceuticals. While absorption by this route is bungling, there are few side effects with conventional ocular dosage forms. Hence, ocular inserts were prepared with prolonged release of drug and minimum swelling within cul-de-sac using ofloxacin as a model drug; Hydroxy propyl methyl cellulose, Methyl cellulose, Poly vinyl pyrrolidone and Poly vinyl alcohol as polymers. PEG-400 was incorporated as plasticizer. The main purpose of the study is to deliver the drug in zero order kinetics. Methods: Solvent casting technique was followed to prepare ofloxacin ocular films. Eight formulations were formulated and subjected to various physicochemical evaluations. Ocular inserts prepared were smooth and passed all the evaluation tests performed. Formulation OF2 shows a maximum cumulative percentage drug release of 91.27 % at the end of 24 hours. Ocuserts formulated also passed the test for sterility. They showed zero-order release of the drug in the in vitro and in vivo release studies. The drug in the films was found to be active against selected microorganisms as was proved by microbial efficacy studies. A high correlation coefficient was found between in vitro and in vivo release rate studies. Shelf-life of the product was found to be more than one year. The results of in vitro, in vivo, kinetic treatment (zero order and Korsemeyer's regression values) and rate constant 'k' value suggest that OF2 was the best formulation among the formulations studied for formulating ofloxacin ocular insert." @default.
- W2247366218 created "2016-06-24" @default.
- W2247366218 creator A5009491878 @default.
- W2247366218 creator A5045757973 @default.
- W2247366218 creator A5056630945 @default.
- W2247366218 date "2006-12-22" @default.
- W2247366218 modified "2023-09-23" @default.
- W2247366218 title "Ofloxacin Ocular Inserts: Design, Formulation and Evaluation" @default.
- W2247366218 hasPublicationYear "2006" @default.
- W2247366218 type Work @default.
- W2247366218 sameAs 2247366218 @default.
- W2247366218 citedByCount "16" @default.
- W2247366218 countsByYear W22473662182012 @default.
- W2247366218 countsByYear W22473662182013 @default.
- W2247366218 countsByYear W22473662182014 @default.
- W2247366218 countsByYear W22473662182015 @default.
- W2247366218 countsByYear W22473662182017 @default.
- W2247366218 crossrefType "journal-article" @default.
- W2247366218 hasAuthorship W2247366218A5009491878 @default.
- W2247366218 hasAuthorship W2247366218A5045757973 @default.
- W2247366218 hasAuthorship W2247366218A5056630945 @default.
- W2247366218 hasConcept C125287762 @default.
- W2247366218 hasConcept C136229726 @default.
- W2247366218 hasConcept C150903083 @default.
- W2247366218 hasConcept C159985019 @default.
- W2247366218 hasConcept C178790620 @default.
- W2247366218 hasConcept C185592680 @default.
- W2247366218 hasConcept C192562407 @default.
- W2247366218 hasConcept C207001950 @default.
- W2247366218 hasConcept C2778049240 @default.
- W2247366218 hasConcept C2778512257 @default.
- W2247366218 hasConcept C2779820397 @default.
- W2247366218 hasConcept C2780035454 @default.
- W2247366218 hasConcept C2780666587 @default.
- W2247366218 hasConcept C43617362 @default.
- W2247366218 hasConcept C501593827 @default.
- W2247366218 hasConcept C521977710 @default.
- W2247366218 hasConcept C55493867 @default.
- W2247366218 hasConcept C58968531 @default.
- W2247366218 hasConcept C71924100 @default.
- W2247366218 hasConcept C86803240 @default.
- W2247366218 hasConcept C98274493 @default.
- W2247366218 hasConceptScore W2247366218C125287762 @default.
- W2247366218 hasConceptScore W2247366218C136229726 @default.
- W2247366218 hasConceptScore W2247366218C150903083 @default.
- W2247366218 hasConceptScore W2247366218C159985019 @default.
- W2247366218 hasConceptScore W2247366218C178790620 @default.
- W2247366218 hasConceptScore W2247366218C185592680 @default.
- W2247366218 hasConceptScore W2247366218C192562407 @default.
- W2247366218 hasConceptScore W2247366218C207001950 @default.
- W2247366218 hasConceptScore W2247366218C2778049240 @default.
- W2247366218 hasConceptScore W2247366218C2778512257 @default.
- W2247366218 hasConceptScore W2247366218C2779820397 @default.
- W2247366218 hasConceptScore W2247366218C2780035454 @default.
- W2247366218 hasConceptScore W2247366218C2780666587 @default.
- W2247366218 hasConceptScore W2247366218C43617362 @default.
- W2247366218 hasConceptScore W2247366218C501593827 @default.
- W2247366218 hasConceptScore W2247366218C521977710 @default.
- W2247366218 hasConceptScore W2247366218C55493867 @default.
- W2247366218 hasConceptScore W2247366218C58968531 @default.
- W2247366218 hasConceptScore W2247366218C71924100 @default.
- W2247366218 hasConceptScore W2247366218C86803240 @default.
- W2247366218 hasConceptScore W2247366218C98274493 @default.
- W2247366218 hasIssue "2" @default.
- W2247366218 hasLocation W22473662181 @default.
- W2247366218 hasOpenAccess W2247366218 @default.
- W2247366218 hasPrimaryLocation W22473662181 @default.
- W2247366218 hasRelatedWork W1977072597 @default.
- W2247366218 hasRelatedWork W2001957633 @default.
- W2247366218 hasRelatedWork W2088187401 @default.
- W2247366218 hasRelatedWork W2089650197 @default.
- W2247366218 hasRelatedWork W2113942606 @default.
- W2247366218 hasRelatedWork W2115439624 @default.
- W2247366218 hasRelatedWork W2119975522 @default.
- W2247366218 hasRelatedWork W2122125802 @default.
- W2247366218 hasRelatedWork W2165919137 @default.
- W2247366218 hasRelatedWork W2266613415 @default.
- W2247366218 hasRelatedWork W2272739701 @default.
- W2247366218 hasRelatedWork W2613790197 @default.
- W2247366218 hasRelatedWork W2784275145 @default.
- W2247366218 hasRelatedWork W2808782282 @default.
- W2247366218 hasRelatedWork W2883631192 @default.
- W2247366218 hasRelatedWork W2977055769 @default.
- W2247366218 hasRelatedWork W41882276 @default.
- W2247366218 hasRelatedWork W2182311580 @default.
- W2247366218 hasRelatedWork W2185723034 @default.
- W2247366218 hasRelatedWork W2188958069 @default.
- W2247366218 hasVolume "5" @default.
- W2247366218 isParatext "false" @default.
- W2247366218 isRetracted "false" @default.
- W2247366218 magId "2247366218" @default.
- W2247366218 workType "article" @default.