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- W2247367782 abstract "The developing mouse reproductive system starts to diverge from the early urinary system at about E10 when the gonad becomes distinct from the mesonephros, with virtually all of its future internal tissues and ducts deriving from the intermediate mesoderm. This chapter reviews the development of the internal and external reproductive tissues and the emergence of sexual dimorphism, linking anatomical change with current knowledge of the many signaling pathways and transcriptions factors that drive it. The roles of these proteins have been clarified by transgenic technology, particularly where gene manipulation can drive partial or complete sex change in the developing gonad, thus showing how phenotypic sex is determined. The discussion points to the need for this regulatory knowledge to be integrated with the proteins networks whose role is to turn molecular signals into novel anatomical phenotypes." @default.
- W2247367782 created "2016-06-24" @default.
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- W2247367782 date "2016-01-01" @default.
- W2247367782 modified "2023-09-26" @default.
- W2247367782 title "The Reproductive System" @default.
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- W2247367782 doi "https://doi.org/10.1016/b978-0-12-800043-4.00009-9" @default.
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