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• W2247396128 abstract "ObjectivesTo assess the risk posed by missing data (MD) to the power and validity of trials evaluating palliative interventions.Study Design and SettingA systematic review of MD in published randomized controlled trials (RCTs) of palliative interventions in participants with life-limiting illnesses was conducted, and random-effects meta-analyses and metaregression were performed. CENTRAL, MEDLINE, and EMBASE (2009–2014) were searched with no language restrictions.ResultsOne hundred and eight RCTs representing 15,560 patients were included. The weighted estimate for MD at the primary endpoint was 23.1% (95% confidence interval [CI] 19.3, 27.4). Larger MD proportions were associated with increasing numbers of questions/tests requested (odds ratio [OR], 1.19; 95% CI 1.05, 1.35) and with longer study duration (OR, 1.09; 95% CI 1.02, 1.17). Meta-analysis found evidence of differential rates of MD between trial arms, which varied in direction (OR, 1.04; 95% CI 0.90, 1.20; I2 35.9, P = 0.001). Despite randomization, MD in the intervention arms (vs. control) were more likely to be attributed to disease progression unrelated to the intervention (OR, 1.31; 95% CI 1.02, 1.69). This was not the case for MD due to death (OR, 0.92; 95% CI 0.78, 1.08).ConclusionThe overall proportion and differential rates and reasons for MD reduce the power and potentially introduce bias to palliative care trials." @default.
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• W2247396128 date "2016-06-01" @default.
• W2247396128 modified "2023-10-18" @default.
• W2247396128 title "Missing data in randomized controlled trials testing palliative interventions pose a significant risk of bias and loss of power: a systematic review and meta-analyses" @default.
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• W2247396128 doi "https://doi.org/10.1016/j.jclinepi.2015.12.003" @default.
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