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• W2247396723 abstract "Gene therapy has been applied to malignant pleural effusion derived from several types of cancer (colon, breast, lung cancer, mesothelioma, ovarian and liver) (1-5). Successful management has been established either with p53 tumor suppression gene therapy (4,5) or gene therapy as immunotherapy (1,3) and currently with pro-drug transformation (antibiotic) to active chemotherapy compound (2). All studies administered the nanocomplexe (viral vector/plasmid DNA) through a tunneled intrapleural catheter to induce local disease management. The nanoparticle used to deliver gene therapy in all previous presented studies was a viral vector. Viral vectors are known to stimulate the immune system and therefore formulate neutralizing antibodies (Nabs) against the nanocomplex (6)." @default.
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• W2247396723 date "2012-12-01" @default.
• W2247396723 modified "2023-10-16" @default.
• W2247396723 title "Gene therapy for lung cancer malignant pleural effusion: current and future nano-biotechnology." @default.
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• W2247396723 doi "https://doi.org/10.3978/j.issn.2218-6751.2012.08.01" @default.
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