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- W2247403934 abstract "IntroductionWe have recently reported that obstructive sleep apnea (OSA) and primary aldosteronism are extremely common in subjects with resistant hypertension (RHTN) and that in these subjects, a significant correlation between serum aldosterone and OSA severity is observed. We hypothesized that aldosterone by increasing sodium and fluid retention worsens neck tissue edema and hence worsens sleep apnea.ConclusionThese preliminary data support our hypothesis that aldosterone-related sodium and fluid retention may result in worsening of sleep apnea in subjects with resistant hypertension that can be partially overcome using mineralocorticoid antagonist spironolactone. Our findings potentially provide mechanistic insight into the relation between aldosterone related OSA and may be clinically important in treating these patients for better management of their hypertension and sleep apnea." @default.
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- W2247403934 date "2008-01-01" @default.
- W2247403934 modified "2023-09-26" @default.
- W2247403934 title "Spironolactone improves aldosterone related obstructive sleep apnea in subjects with resistant hypertension" @default.
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