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• W224744765 abstract "Homocysteine is an intermediate formed during the metabolism of methionine to cysteine, and high levels of blood plasma homocysteine are considered to be a risk factor for heart attack and stroke. It exists in either its reduced (homocysteine, RSH) or oxidized form (homocystine, RSSR), and the oxidized form the major one in human blood plasma. Since it contains sulfur in its structure, it was also used to modify the electrode surface for the electrocatalytic detection of another compound, such as catecholamine. Homocysteine is usually determined by using fluorescence, UV/Vis and electrochemical detection methods. Spectroscopic detection requires derivatization of homocysteine, and electrochemical detection needs electrodes that enable continuous measurements. However, electrochemical detection has a representative advantage, which is to be able to detect homocysteine without any additional derivatization, if electrodes are free from adsorption. Modified electrodes can solve the problem caused by adsorption and then have high reproducibility for repetitive measurements. A self-assembly technique for electrode modification is simple and has diverse materials for modification. A number of organic compounds containing the thiol group can readily adsorb on the electrode surface, such as gold, and form a self-assembled monolayer (SAM). Macrocyclic complexes with an electrocatalytic effect can be used to determine homocysteine for higher sensitivity and reproducibility, if they can form a SAM on the electrode surface. Previous studies have shown that compounds with sulfur, such as thiophene and its derivatives, and disulfide compounds of 6-mercaptopurine and mercaptobenzimidazole, formed a stable SAM. Although it may be difficult to synthesize macrocyclic complexes containing sulfur, using these materials can extend the fields for the determination of homocysteine. In this work, Ni(II)-macrocyclic complex with thiophene groups (NiMCT) was synthesized and used to form a SAM on a gold electrode surface. A gold electrode modified with the SAM of NiMCT (NiMCT SAM) was characterized spectroscopically and electrochemically. It was used to determine homocysteine by differential pulse voltammetry and its reproducibility was examined for repetitive measurements. The oxidation process of homocysteine at the NiMCT-SAM modified electrode is discussed. Experimental Section" @default.
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• W224744765 date "2006-10-20" @default.
• W224744765 modified "2023-10-16" @default.
• W224744765 title "Self-Assembled Monolayer of Ni(II)-Macrocyclic Complex Containing Thiophene for the Determination of Homocysteine" @default.
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• W224744765 doi "https://doi.org/10.5012/bkcs.2006.27.10.1701" @default.
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