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- W2247457850 abstract "The cost of determining the complete sequence of a bacterial genome has been drastically reduced due to the development of low-cost DNA sequencing methods. This creates a number of new possibilities for understanding the basic biology of probiotic and starter culture bacteria, as well as for strain characterisation at a high level of resolution. The genome sequence of 10 industrial Streptococcus thermophilus strains was determined. Analysis of these sequences and comparison to the three publicly available S. thermophilus complete genome sequences revealed a number of genes not previously described in this species and details the diversity contained in this small set of industrial strains. Differences between strains include single nucleotide polymorphisms, as well as the acquisition or loss of contiguous DNA sequences. None of the acquired DNA contains genes which would be considered undesirable in the food supply. It is anticipated that as sequencing costs decrease further, low-cost genome sequencing will become the most cost-effective way to perform a variety of genetic characterisations of bacteria. This includes characterisations that may be required by regulatory agencies before a new probiotic or starter culture can be introduced into the food supply." @default.
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- W2247457850 date "2009-01-01" @default.
- W2247457850 modified "2023-09-23" @default.
- W2247457850 title "Functional genomics of dairy micro-organisms and probiotics in the era of low-cost DNA sequencing" @default.
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