Matches in SemOpenAlex for { <https://semopenalex.org/work/W2247458899> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2247458899 endingPage "5554" @default.
- W2247458899 startingPage "5554" @default.
- W2247458899 abstract "5554 Background: RAI-refractory thyroid cancer carries a poor prognosis, and no effective systemic therapy exists. DEP is a potent histone deacetylase inhibitor with broad in vitro and phase I anti-tumor activity, and has restored sodium-iodide symporter expression and RAI avidity in thyroid cancer cell lines. Methods: Eligible pts have confirmed papillary, follicular, or Hürthle cell carcinoma, progressive measurable disease, and adequate hepatic/renal function. All pts are RAI-refractory by diagnostic RAI whole body scan (WBS). Prior chemotherapy in the recurrent/metastatic setting, and history of significant cardiac disease are exclusions. DEP 13 mg/m 2 IV is given on day 1, 8, and 15, every 28 days. A novel Simon 2-stage design specifies an initial accrual of 21 pts, with expansion to 41 total pts if 2 RECIST responses or 6 pts with PFS at 6 months are observed. Primary outcome is RECIST response rate. Change in RAI avidity (by diagnostic RAI WBS) is a secondary outcome. Results: To date, 14 pts have been enrolled: female 50%, median age 62 (42–78), median Karnofsky 90 (70–100), papillary/follicular/Hürthle histology (7/1/6). Grade 3–5 toxicities possibly related to drug: grade 5 sudden death (1); no grade 4 toxicity; grade 3 toxicity - fatigue (1), dysphagia (1), dyspnea (1). No grade 3 thrombocytopenia (phase I DLT) has been observed. Grade 1 (6) and grade 2 (4) fatigue have been common. As a result of the grade 5 event, protocol accrual and treatment were suspended temporarily. After NCI-CTEP review, more restrictive cardiac exclusions were added and protocol accrual was resumed. Response at 2 months: stable disease (4); progression (2); inevaluable (6, due to protocol suspension); withdrew consent (1); too early (1). In a proof-of-principle event, clinically significant restoration of RAI avidity was observed in a 78 year-old woman with papillary carcinoma. Per protocol, she was taken off study and given treatment-dose RAI; post-therapy WBS confirmed dramatic RAI avidity. Conclusions: Preliminary signs of in vivo reversal of RAI resistance have been observed. Accrual continues with more restrictive cardiac exclusions, and close surveillance for cardiac events. No significant financial relationships to disclose." @default.
- W2247458899 created "2016-06-24" @default.
- W2247458899 creator A5005775817 @default.
- W2247458899 creator A5009898984 @default.
- W2247458899 creator A5013674989 @default.
- W2247458899 creator A5018114434 @default.
- W2247458899 creator A5039134854 @default.
- W2247458899 creator A5047041628 @default.
- W2247458899 creator A5052713925 @default.
- W2247458899 creator A5072271778 @default.
- W2247458899 creator A5072349810 @default.
- W2247458899 creator A5087689377 @default.
- W2247458899 date "2006-06-20" @default.
- W2247458899 modified "2023-10-16" @default.
- W2247458899 title "A phase II study of single agent depsipeptide (DEP) in patients (pts) with radioactive iodine (RAI)-refractory, metastatic, thyroid carcinoma: Preliminary toxicity and efficacy experience" @default.
- W2247458899 doi "https://doi.org/10.1200/jco.2006.24.18_suppl.5554" @default.
- W2247458899 hasPublicationYear "2006" @default.
- W2247458899 type Work @default.
- W2247458899 sameAs 2247458899 @default.
- W2247458899 citedByCount "16" @default.
- W2247458899 countsByYear W22474588992012 @default.
- W2247458899 countsByYear W22474588992017 @default.
- W2247458899 crossrefType "journal-article" @default.
- W2247458899 hasAuthorship W2247458899A5005775817 @default.
- W2247458899 hasAuthorship W2247458899A5009898984 @default.
- W2247458899 hasAuthorship W2247458899A5013674989 @default.
- W2247458899 hasAuthorship W2247458899A5018114434 @default.
- W2247458899 hasAuthorship W2247458899A5039134854 @default.
- W2247458899 hasAuthorship W2247458899A5047041628 @default.
- W2247458899 hasAuthorship W2247458899A5052713925 @default.
- W2247458899 hasAuthorship W2247458899A5072271778 @default.
- W2247458899 hasAuthorship W2247458899A5072349810 @default.
- W2247458899 hasAuthorship W2247458899A5087689377 @default.
- W2247458899 hasConcept C121332964 @default.
- W2247458899 hasConcept C121608353 @default.
- W2247458899 hasConcept C126322002 @default.
- W2247458899 hasConcept C141071460 @default.
- W2247458899 hasConcept C142424586 @default.
- W2247458899 hasConcept C143998085 @default.
- W2247458899 hasConcept C2776694085 @default.
- W2247458899 hasConcept C2778822529 @default.
- W2247458899 hasConcept C2779761222 @default.
- W2247458899 hasConcept C2781461381 @default.
- W2247458899 hasConcept C29730261 @default.
- W2247458899 hasConcept C71924100 @default.
- W2247458899 hasConcept C87355193 @default.
- W2247458899 hasConcept C90924648 @default.
- W2247458899 hasConceptScore W2247458899C121332964 @default.
- W2247458899 hasConceptScore W2247458899C121608353 @default.
- W2247458899 hasConceptScore W2247458899C126322002 @default.
- W2247458899 hasConceptScore W2247458899C141071460 @default.
- W2247458899 hasConceptScore W2247458899C142424586 @default.
- W2247458899 hasConceptScore W2247458899C143998085 @default.
- W2247458899 hasConceptScore W2247458899C2776694085 @default.
- W2247458899 hasConceptScore W2247458899C2778822529 @default.
- W2247458899 hasConceptScore W2247458899C2779761222 @default.
- W2247458899 hasConceptScore W2247458899C2781461381 @default.
- W2247458899 hasConceptScore W2247458899C29730261 @default.
- W2247458899 hasConceptScore W2247458899C71924100 @default.
- W2247458899 hasConceptScore W2247458899C87355193 @default.
- W2247458899 hasConceptScore W2247458899C90924648 @default.
- W2247458899 hasIssue "18_suppl" @default.
- W2247458899 hasLocation W22474588991 @default.
- W2247458899 hasOpenAccess W2247458899 @default.
- W2247458899 hasPrimaryLocation W22474588991 @default.
- W2247458899 hasRelatedWork W2003938723 @default.
- W2247458899 hasRelatedWork W2047967234 @default.
- W2247458899 hasRelatedWork W2118496982 @default.
- W2247458899 hasRelatedWork W2351796763 @default.
- W2247458899 hasRelatedWork W2418204902 @default.
- W2247458899 hasRelatedWork W2439875401 @default.
- W2247458899 hasRelatedWork W2569260518 @default.
- W2247458899 hasRelatedWork W3134757250 @default.
- W2247458899 hasRelatedWork W4237386702 @default.
- W2247458899 hasRelatedWork W2525756941 @default.
- W2247458899 hasVolume "24" @default.
- W2247458899 isParatext "false" @default.
- W2247458899 isRetracted "false" @default.
- W2247458899 magId "2247458899" @default.
- W2247458899 workType "article" @default.