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- W2247461483 abstract "ABSTRACT Efficient means to overcome chemotherapy resistance in melanoma and clinically useful tools to predict the response are lacking. We have performed proteomics and microarray gene expression profiling of pre-treatment metastases from melanoma patients with different response to DNA alkylating agents dacarbazine (DTIC) or temozolomide (TMZ). Functional categories identified by both gene expression and proteomics profiling include regulation of the cell cycle, cell death, developmental processes, transcription, transport functions, immune system processes and several cell signaling pathways. Twelve candidates were identified in both analyses. In a second independent study, gene expression was analyzed in pre- and post-treatment biopsies from the same patients, and genes that were upregulated after DTIC/TMZ treatment in metastases from non-responders were identified. Five of these genes had also been identified as resistance candidates in the first studies. Many of the same biological pathways were also identified, including “actin cytoskeleton signaling”which is among the top significantly overrepresented functional categories in all studies. Several candidates have been validated in an extended set of tumor biopsies from melanoma patients with different response to DTIC/TMZ. We have also performed in vitro studies using different melanoma cell lines and tested if siRNA inhibition of selected candidates can affect chemosensitivity." @default.
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- W2247461483 date "2012-06-01" @default.
- W2247461483 modified "2023-09-30" @default.
- W2247461483 title "P2.17 Proteomics and Gene Expression Profiling of Melanoma Chemotherapy Response in Tumors" @default.
- W2247461483 doi "https://doi.org/10.1016/s0923-7534(20)31340-5" @default.
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