FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2247476735> ?p ?o ?g. }

• W2247476735 abstract "Differentiation and epithelial-mesenchymal transition (EMT) in mammary epithelial cell were analyzed with respect to the epigenetic gene regulation. In the first part, the chromatin accessibility at the beta-casein promoter and the role of histone 3 lysine 9 Dimethylation (H3K9me2) in transcriptional regulation of beta-casein gene in HC11 cells were studied. Moreover, the function of the JmjC domain-containing demethylase Jmjd1a in beta-casein expression was also analyzed. The results revealed that the beta-casein promoter is inaccessible in HC11 cells, and the inaccessibility is independent of hormone treatment. Moreover, the repressive histone mark H3K9me2 is associated at beta-casein promoter. Since the associated H3K9me2 is correlated to chromatin inaccessibility, it probably represses the beta-casein gene. Although the overexpression of Jmjd1a essential domains reduces global H3K9me2 level, beta-casein expression is still not upregulated. This is, at least in part, due to the inhibitory effect of Jmjd1a domains on transcription machinery. In the second part, the role of histone 3 lysine 27 Trimethylation (H3K27me3) in regulation of EMT was analyzed. The finding revealed that H3K27me3 regulates EMT at levels of marker genes, Snail, but not the master regulator. The promoters of both epithelial marker Cdh1 and the mesenchymal marker Acta2 are associated with H3K27me3 and the associations correlate to gene transcription. In addition, Snail is a target of H3K27me3, since removal of H3K27me3 by both DZNep and Suz12 knockdown can equally enhance the TGFβ3 mediated induction of Snail mRNA. TGFβ3 is essential. Finally, the CBF-A/KAP-1/FTS-1 complex might not be regulated by H3K27me3. Besides, DZNep is identified to be a novel EMT inducer and the effect results, at least in part, from the activation of the CBF-A/KAP-1/FTS-1 complex." @default.
• W2247476735 created "2016-06-24" @default.
• W2247476735 creator A5040620635 @default.
• W2247476735 date "2012-01-03" @default.
• W2247476735 modified "2023-09-26" @default.
• W2247476735 title "Epigenetic gene regulation of differentiation and epithelial-mesenchymal transition in mammary epithelial cells" @default.
• W2247476735 cites W132416300 @default.
• W2247476735 cites W1504303645 @default.
• W2247476735 cites W1571557749 @default.
• W2247476735 cites W1603378909 @default.
• W2247476735 cites W1757349669 @default.
• W2247476735 cites W1775510084 @default.
• W2247476735 cites W1837711156 @default.
• W2247476735 cites W1967061237 @default.
• W2247476735 cites W1969691479 @default.
• W2247476735 cites W1972731253 @default.
• W2247476735 cites W1974586435 @default.
• W2247476735 cites W1976739900 @default.
• W2247476735 cites W1979440527 @default.
• W2247476735 cites W1982999513 @default.
• W2247476735 cites W1983163251 @default.
• W2247476735 cites W1985180051 @default.
• W2247476735 cites W1985754783 @default.
• W2247476735 cites W1986911605 @default.
• W2247476735 cites W1987687886 @default.
• W2247476735 cites W1996118868 @default.
• W2247476735 cites W1997387647 @default.
• W2247476735 cites W2009420762 @default.
• W2247476735 cites W2010867675 @default.
• W2247476735 cites W2015668518 @default.
• W2247476735 cites W2017337742 @default.
• W2247476735 cites W2019171053 @default.
• W2247476735 cites W2023600869 @default.
• W2247476735 cites W2024457272 @default.
• W2247476735 cites W2026404162 @default.
• W2247476735 cites W2029865263 @default.
• W2247476735 cites W2030571655 @default.
• W2247476735 cites W2032942532 @default.
• W2247476735 cites W2033477334 @default.
• W2247476735 cites W2035653659 @default.
• W2247476735 cites W2035657811 @default.
• W2247476735 cites W2036286713 @default.
• W2247476735 cites W2036609581 @default.
• W2247476735 cites W2036917468 @default.
• W2247476735 cites W2037562549 @default.
• W2247476735 cites W2038569449 @default.
• W2247476735 cites W2040498319 @default.
• W2247476735 cites W2050562341 @default.
• W2247476735 cites W2051174713 @default.
• W2247476735 cites W2051320963 @default.
• W2247476735 cites W2054282870 @default.
• W2247476735 cites W2054643318 @default.
• W2247476735 cites W2056054628 @default.
• W2247476735 cites W2059059097 @default.
• W2247476735 cites W2060507483 @default.
• W2247476735 cites W2060903701 @default.
• W2247476735 cites W2066430720 @default.
• W2247476735 cites W2067139290 @default.
• W2247476735 cites W2067583299 @default.
• W2247476735 cites W2068065167 @default.
• W2247476735 cites W2068157186 @default.
• W2247476735 cites W2076446466 @default.
• W2247476735 cites W2077986050 @default.
• W2247476735 cites W2092562080 @default.
• W2247476735 cites W2093157637 @default.
• W2247476735 cites W2096083625 @default.
• W2247476735 cites W2099368049 @default.
• W2247476735 cites W2103270060 @default.
• W2247476735 cites W2106921118 @default.
• W2247476735 cites W2113634596 @default.
• W2247476735 cites W2115347412 @default.
• W2247476735 cites W2121136307 @default.
• W2247476735 cites W2122349103 @default.
• W2247476735 cites W2123552387 @default.
• W2247476735 cites W2125862391 @default.
• W2247476735 cites W2127431151 @default.
• W2247476735 cites W2130907138 @default.
• W2247476735 cites W2133148543 @default.
• W2247476735 cites W2134203671 @default.
• W2247476735 cites W2143658931 @default.
• W2247476735 cites W2144132301 @default.
• W2247476735 cites W2144616702 @default.
• W2247476735 cites W2144792857 @default.
• W2247476735 cites W2148276020 @default.
• W2247476735 cites W2155357606 @default.
• W2247476735 cites W2156734818 @default.
• W2247476735 cites W2161841622 @default.
• W2247476735 cites W2168220276 @default.
• W2247476735 cites W2171256063 @default.
• W2247476735 cites W4553897 @default.
• W2247476735 cites W53226733 @default.
• W2247476735 cites W2004499293 @default.
• W2247476735 hasPublicationYear "2012" @default.
• W2247476735 type Work @default.
• W2247476735 sameAs 2247476735 @default.
• W2247476735 citedByCount "0" @default.
• W2247476735 crossrefType "dissertation" @default.
• W2247476735 hasAuthorship W2247476735A5040620635 @default.
• W2247476735 hasConcept C101762097 @default.
• W2247476735 hasConcept C104317684 @default.

• next