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- W2247482695 endingPage "39306" @default.
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- W2247482695 abstract "A series of pentacyclic tritperpenes found in Perilla frutescens (P. frutescens), including ursolic acid (UA), oleanolic acid (OA), corosolic acid (CA), 3-epi-corosolic acid (3-epiCA), maslinic acid (MA), and 3-epi-maslinic acid (3-epiMA) were evaluated for their effects on epidermal cell signaling, proliferation, and skin inflammation in relation to their ability to inhibit skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA) and compared to UA as the prototype compound. All compounds were given topically 30 min prior to each TPA application and significantly inhibited skin tumor promotion. 3-epiCA and MA were significantly more effective than UA at inhibiting tumor development. All of these compounds significantly inhibited epidermal proliferation induced by TPA, however, CA, 3-epiCA and MA were more effective than UA. All compounds also reduced skin inflammation (assessed by infiltration of mast cells and T-cells) and inflammatory gene expression induced by TPA, however, 3-epiCA and MA were again more effective than UA. The greater ability of 3-epiCA and MA to inhibit skin tumor promotion was associated with greater reduction of Cox-2 and Twist1 proteins and inhibition of activation (i.e., phosphorylation) of IGF-1R, STAT3 and Src. Further study of these compounds, especially 3-epiCA and MA, for chemopreventive activity in other cancer model systems is warranted." @default.
- W2247482695 created "2016-06-24" @default.
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- W2247482695 date "2015-10-15" @default.
- W2247482695 modified "2023-10-16" @default.
- W2247482695 title "Evaluation of pentacyclic triterpenes found in<i>Perilla frutescens</i>for inhibition of skin tumor promotion by 12-<i>O</i>-tetradecanoylphorbol-13-acetate" @default.
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- W2247482695 doi "https://doi.org/10.18632/oncotarget.5751" @default.
- W2247482695 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4770773" @default.
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- W2247482695 hasPublicationYear "2015" @default.
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