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• W2247486186 abstract "591 Background: Overweight and obesity are often associated with an increased risk of dying from breast cancer and poor outcomes of therapy. Tumor characteristics are relevant in prognosis and treatment of breast cancer and potentially strongly associated with the body mass index. Methods: The ADEBAR study is a german multicenter phase III trial (n = 1,502) with the goal to evaluate whether breast cancer (BC) pts with > 3 axillary lymph node metastases benefit from a sequential anthracycline-docetaxel regimen (EC - Doc) compared to dose-intensive anthracycline-containing polychemotherapy (FEC). For our evaluation Adebar-Patients were grouped according the WHO global database on body mass index (BMI). Results: There is a strong correlation between BMI, age and menopausal status at clinical diagnosis of breast cancer. Overweight and obese patients in median are 55 years old (range 27-71 year) and already postmenopausal (70%, n = 540). This analysis shows no connection of tumor localisation (unilateral left or right and bilateral breast cancer) and BMI. The tumor size at clinical diagnosis was strongly associated to the patient's weight (< 0.0001). Breast tumors in overweight and obese patients have shown a size > 3 cm in 61 % (n = 479) and a size > 5 cm in 72% (n = 111). In underweight, normal, overweight as well obese patients there was no sign for a significant difference in the number of positive lymph nodes (p = 0.2890), tumor histology (p = 0.9750) and grading (p = 0.9520). Breast Cancer Positivity for ER and PR hormone receptors (ER p = 0.9708, PR p = 0.7785) and the expression of HER2 at the tumor surface (p = 0.1710) were not significant associated to overweight and obesity in study patients. Conclusions: Our analysis shows a highly significant coherence between BMI and tumor size in patients with early stage node positive breast cancer. This finding is in line with current publications which show that overweight and obese woman's have often been diagnosed at a more advanced stage of disease and the treatment in this patients being less effective as a consequence. Weight reduction might be an additional approach on breast cancer therapy and prevention. No significant financial relationships to disclose." @default.
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• W2247486186 date "2010-05-20" @default.
• W2247486186 modified "2023-09-25" @default.
• W2247486186 title "Obesity and tumor characteristics in nodal-positive early-stage breast cancer: Results of the German ADEBAR study." @default.
• W2247486186 doi "https://doi.org/10.1200/jco.2010.28.15_suppl.591" @default.
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