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- W2247495233 abstract "The pattern of plasma androgen levels was assessed in 5 oligomenorrheic women being treated with clomiphene citrate (Clomid). The changes during the Clomid-induced ovulatory cycles were compared with those during the spontaneous menstrual cycle in 4 normal women. Plasma testosterone (T), androstenedione (A), and an index of the free plasma T levels were measured by competitive protein-binding assay. No significant fluctuations in plasma T or A were apparent during the normal menstrual cycle. In contrast, during 4 of the 5 Clomid-treated cycles increased plasma A and T concentrations were demonstrated within 3 to 10 days following cessation of Clomid administration, the absolute concentrations often exceeding 2 S.D. of the normal mean levels. The elevated T levels following Clomid were seemingly due to an increased T production since the free T levels were also increased. The results demonstrate that Clomid induces hyperandrogenism in some oligomenorrheic women. This increase, most likely reflecting ovarian production and secretion, may interfere with normal ovulatory function." @default.
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- W2247495233 date "1973-02-01" @default.
- W2247495233 modified "2023-10-07" @default.
- W2247495233 title "Sequential changes in total and free testosterone and androstenedione in plasma during spontaneous and Clomid-induced ovulatory cycles" @default.
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- W2247495233 doi "https://doi.org/10.1016/0002-9378(73)90394-3" @default.
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