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- W2247495521 abstract "Aim: To compare distributions of volumes of different glomeruli within individuals, by ethnic group. Background: We have described volume heterogeneity of volumes of glomeruli within individuals (IgVs). And proposed that greater volume heterogeneity and net glomerular enlargement mark glomerular stress. Here we compare IgVs of US whites, US Blacks, Senegalese from West Africa and Australian Aborigines. Methods: We measured the volume of multiple glomeruli without sclerosis in the right kidney of adult males undergoing autopsy for sudden or unexpected death. They had no gross renal abnormalities, and no documented renal disease. Thirty glomeruli, 10 from the outer, middle and inner cortical zones, were measured by the Cavalieri method. Subjects were mostly matched within 5 years, but occasionally within <10 years of age. Mean IgVs and IgV variances were compared between groups, accounting for intraindividual IGV heterogeneity. Results: Mean (SD) IgVs in the matched groups were as follows: US whites vs Senegalese, n = 18 each, 3.9(0.9) vs 3.9(1.0), p = 0.97; Senegalese vs US Blacks, n = 19 each, 3.9(0.9) vs 4.8(1.3), p = 0.007; US Blacks vs Australian Aborigines, n = 10 each, 5.1(1.8) vs 5.2(2.0), p = 0.92. The IgV SDs were also significantly different for the Senegalese vs US Black analyses. The visual similarities in IgV distributions of US whites and Senegalese were striking, as were the differences between the Senegalese and both US Blacks and Australian Aborigines. Conclusions: Net glomerular enlargement and greater volume heterogeneity mark US Blacks and Australian Aborigines, both populations at high risk for hypertension and renal disease. The geographic and epidemiologic transitions over centuries seem to have predisposed US Blacks to higher risk than people from West Africa, with whom they share some genetic heritage." @default.
- W2247495521 created "2016-06-24" @default.
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- W2247495521 date "2009-01-01" @default.
- W2247495521 modified "2023-09-27" @default.
- W2247495521 title "Comparison by racial groups of the distribution of volumes of different glomeruli within individuals" @default.
- W2247495521 hasPublicationYear "2009" @default.
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