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- W2247502169 abstract "Heart failure is a common and increasing problem associated with a high morbidity and mortality. The high morbidity of heart failure imposes the majority of costs of its treatment. Hospitalization among patients with heart failure is frequent, increasing, recurrent and often prolonged and constitutes about 65% of health spending on heart failure. A number of strategies can be envisaged to reduce recurrent heart failure hospitalization. ACE inhibitors (especially high-dose), beta-blockers, spironolactone and possibly digoxin, have all been shown to reduce substantially all-cause hospitalization in patients with heart failure in double-blind controlled trials. The most common single reason for re-admission is for worsening heart failure which may frequently be exacerbated by incomplete and unpredictable absorption of some diuretics. The loop diuretic, torasemide, because of its favourable pharmacokinetic and pharmacodynamic profile may be able to prevent worsening of underlying heart failure developing into a crisis, leading to hospitalization. Studies confirm that treatment with torasemide can reduce the rate of hospitalization due to worsening heart failure and is cost-effective, A stumbling block to progress that is often encountered is the unwillingness of budget holders to spend a small amount of money on better drugs and outpatient services in order to prevent hospitalization. This is exacerbated in many countries by a separate system for care of patients in and out of hospital." @default.
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- W2247502169 date "2001-07-01" @default.
- W2247502169 modified "2023-09-27" @default.
- W2247502169 title "Pharmacoeconomics in heart failure: impact of drug and non-drug based treatment" @default.
- W2247502169 doi "https://doi.org/10.1016/s0195-668x(01)80005-1" @default.
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