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- W2247544268 abstract "STAT3 is a transcription factor that plays an oncogenic role in many cancers, but STAT3 has proven difficult to target with chemical inhibitors. Hong et al . demonstrated that antisense technology is a feasible alternative to small-molecule inhibitors for targeting STAT3. The authors used high-affinity, next-generation antisense oligonucleotides, which have higher potency than previous generations and can be systemically administered without a lipid vehicle. One of these new antisense oligonucleotides, AZD9150, demonstrated activity in various preclinical cancer models, as well as in cancer patients who had failed one or more previous treatments, paving the way for additional clinical testing of this therapy. D. Hong, R. Kurzrock, Y. Kim, R. Woessner, A. Younes, J. Nemunaitis, N. Fowler, T. Zhou, J. Schmidt, M. Jo, S. J. Lee, M. Yamashita, S. G. Hughes, L. Fayad, S. Piha-Paul, M. V. P. Nadella, M. Mohseni, D. Lawson, C. Reimer, D. C. Blakey, X. Xiao, J. Hsu, A. Revenko, B. P. Monia, A. R. MacLeod, AZD9150, a next-generation antisense oligonucleotide inhibitor of STAT3 with early evidence of clinical activity in lymphoma and lung cancer. Sci. Transl. Med. 7 , 314ra185 (2015). [Abstract]" @default.
- W2247544268 created "2016-06-24" @default.
- W2247544268 creator A5057314206 @default.
- W2247544268 date "2015-11-24" @default.
- W2247544268 modified "2023-09-25" @default.
- W2247544268 title "Blocking transcription in tumors, STAT" @default.
- W2247544268 doi "https://doi.org/10.1126/scisignal.aad9035" @default.
- W2247544268 hasPublicationYear "2015" @default.
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