Matches in SemOpenAlex for { <https://semopenalex.org/work/W2247548080> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2247548080 abstract "1. Three members of a family with a haemorrhagic tendency are described. The hereditary features of the condition are presented, with the suggestion that the bleeding tendency is inherited either through a recessive gene or through a dominant gene with poor penetrance.2. The deficient factor in the coagulation mechanism of these patients is shown to be associated with prothrombin activation. The children of the affected individuals, though without symptoms, are shown to have a mild coagulation defect of the same type. Other factors concerned in blood coagulation, viz. platelets, calcium, and fibrinogen, are normal. The deficiency is reflected in the prolongation of the prothrombin time as estimated by Quick's one-stage method.3. Experimental evidence is produced showing that the patients' plasma contained a normal concentration of prothrombin, but that the labile factor of Quick (ac-globulin of Seegers; factor v of Owren) was lacking.4. The first reported case of an undoubtedly similar deficiency was that of Owren (1947). In Owren's patient, however, the condition did not appear to be hereditary. More recent reports by Frank, Bilhan, and Ekren (1950) and de Vries, Matoth, and Shamir (1951) bear out the hereditary nature of the condition.5. Fresh plasma has been found therapeutically effective in controlling the haemorrhages. The alterations in prothrombin time after transfusions were compared during haemorrhage and when no bleeding was taking place. From the results it is concluded that the deficient factor acts like a catalyst, and not as a substance used up during clot-formation.6. Observations were made on the effect of vitamin K, protamine sulphate, and aminophylline on the level of the labile factor in the plasma. Varied fluctuations in the prothrombin time made it difficult to form conclusions as to the way in which any of these substances might alter it, especially if the change brought about was a small one. No regular pattern of fluctuation could be detected in the course of days or weeks." @default.
- W2247548080 created "2016-06-24" @default.
- W2247548080 creator A5032682174 @default.
- W2247548080 creator A5054640183 @default.
- W2247548080 date "1952-01-01" @default.
- W2247548080 modified "2023-09-27" @default.
- W2247548080 title "A FAMILIAL DISORDER OF BLOOD COAGULATION DUE TO DEFICIENCY OF THE LABILE FACTOR<sup>1</sup>" @default.
- W2247548080 doi "https://doi.org/10.1093/oxfordjournals.qjmed.a066641" @default.
- W2247548080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14900384" @default.
- W2247548080 hasPublicationYear "1952" @default.
- W2247548080 type Work @default.
- W2247548080 sameAs 2247548080 @default.
- W2247548080 citedByCount "16" @default.
- W2247548080 crossrefType "journal-article" @default.
- W2247548080 hasAuthorship W2247548080A5032682174 @default.
- W2247548080 hasAuthorship W2247548080A5054640183 @default.
- W2247548080 hasConcept C104317684 @default.
- W2247548080 hasConcept C126322002 @default.
- W2247548080 hasConcept C127716648 @default.
- W2247548080 hasConcept C185592680 @default.
- W2247548080 hasConcept C200544954 @default.
- W2247548080 hasConcept C203014093 @default.
- W2247548080 hasConcept C2778382381 @default.
- W2247548080 hasConcept C2779036427 @default.
- W2247548080 hasConcept C2780434524 @default.
- W2247548080 hasConcept C55493867 @default.
- W2247548080 hasConcept C71924100 @default.
- W2247548080 hasConcept C89560881 @default.
- W2247548080 hasConcept C90924648 @default.
- W2247548080 hasConceptScore W2247548080C104317684 @default.
- W2247548080 hasConceptScore W2247548080C126322002 @default.
- W2247548080 hasConceptScore W2247548080C127716648 @default.
- W2247548080 hasConceptScore W2247548080C185592680 @default.
- W2247548080 hasConceptScore W2247548080C200544954 @default.
- W2247548080 hasConceptScore W2247548080C203014093 @default.
- W2247548080 hasConceptScore W2247548080C2778382381 @default.
- W2247548080 hasConceptScore W2247548080C2779036427 @default.
- W2247548080 hasConceptScore W2247548080C2780434524 @default.
- W2247548080 hasConceptScore W2247548080C55493867 @default.
- W2247548080 hasConceptScore W2247548080C71924100 @default.
- W2247548080 hasConceptScore W2247548080C89560881 @default.
- W2247548080 hasConceptScore W2247548080C90924648 @default.
- W2247548080 hasLocation W22475480801 @default.
- W2247548080 hasLocation W22475480802 @default.
- W2247548080 hasOpenAccess W2247548080 @default.
- W2247548080 hasPrimaryLocation W22475480801 @default.
- W2247548080 hasRelatedWork W138378723 @default.
- W2247548080 hasRelatedWork W1448260196 @default.
- W2247548080 hasRelatedWork W15481497 @default.
- W2247548080 hasRelatedWork W1976497079 @default.
- W2247548080 hasRelatedWork W1985614479 @default.
- W2247548080 hasRelatedWork W1997081034 @default.
- W2247548080 hasRelatedWork W2039907534 @default.
- W2247548080 hasRelatedWork W2051545204 @default.
- W2247548080 hasRelatedWork W2053264658 @default.
- W2247548080 hasRelatedWork W2060780299 @default.
- W2247548080 hasRelatedWork W2074150782 @default.
- W2247548080 hasRelatedWork W2084263081 @default.
- W2247548080 hasRelatedWork W2138495430 @default.
- W2247548080 hasRelatedWork W2142719453 @default.
- W2247548080 hasRelatedWork W2295398996 @default.
- W2247548080 hasRelatedWork W2314728769 @default.
- W2247548080 hasRelatedWork W2324647598 @default.
- W2247548080 hasRelatedWork W2327156311 @default.
- W2247548080 hasRelatedWork W2417220161 @default.
- W2247548080 hasRelatedWork W2409231053 @default.
- W2247548080 isParatext "false" @default.
- W2247548080 isRetracted "false" @default.
- W2247548080 magId "2247548080" @default.
- W2247548080 workType "article" @default.