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- W2247604919 abstract "We have reported the autoantibody response to microsomal epoxide hydrolase (mEH) in patients with hepatitis C and A (J. Autoimmunity 28:7, 2007). In another poster in this meeting, we demonstrated that RNA virus infection induced surface expression of mEH on hepatocyte cell lines, and made the cells more sensitive to a potent carcinogen DMBA. To analyze the topological changes of mEH in these conditions, we developed five groups of monoclonal antibodies with different epitope specificities as determined by ELISA with truncated mEH, western blotting and competitive binding assay. Three (type I to III) recognized the N-terminus, one (type IV) recognized the C-terminus, and one (type V) recognized only the conformational epitope. FACS analysis showed that all the epitopes except type IV were expressed on the surface of freshly isolated hepatocytes whereas none were detected on an immortalized hepatocyte cell line. When this cell line was infected with RNA viruses, only the type V was induced on the surface. A differentiated hepatocellular carcinoma (HCC) line, Huh7 also exhibited only the type V epitope on the surface, and its expression was enhanced by virus infection. An undifferentiated HCC line, HuH1 showed all the epitopes on the surface. These monoclonal antibodies seem to be useful to analyze the role of mEH in pathological conditions." @default.
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- W2247604919 date "2008-03-01" @default.
- W2247604919 modified "2023-10-14" @default.
- W2247604919 title "Analysis of the topology of the microsomal epoxide hydrolase on the cell surface with monoclonal antibodies with different epitope specificities" @default.
- W2247604919 doi "https://doi.org/10.1096/fasebj.22.1_supplement.479.31" @default.
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