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- W2247690692 abstract "10037 Background: No further treatment of relapse after high-dose chemotherapy (HDC) and stem cell transplantation (SCT) has been described yet. Patients treated at our centre can undergo phase I-II studies or palliative treatments. We present herewith our experience on VP16 in relapsing or progressing patients after HDC and SCT. Methods: VP16 was administered orally at the dose of 100 mg/m2/day for 3 consecutive days for 3 consecutive weeks with a stop of one week between the courses. It continued until evidence of clinical progression. Patients who received 1 to 2 courses were considered non-responders, those who received 2–4 courses poor- responders and those who received more than 4 courses good-responders. Results: From 1985 to 2006, 69 patients were treated with oral VP16 which was first-line relapse chemotherapy in 46 patients, second-line in 19, and third-line in 4. They received a total of 342 courses with a median of 3 (1–21) courses. 28 patients (40.5%) were non-responders, 17 (24.7%) poor resp..." @default.
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- W2247690692 date "2008-05-20" @default.
- W2247690692 modified "2023-10-08" @default.
- W2247690692 title "Palliative treatment in neuroblastoma: Etoposide (VP16), an effective drug" @default.
- W2247690692 doi "https://doi.org/10.1200/jco.2008.26.15_suppl.10037" @default.
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