Matches in SemOpenAlex for { <https://semopenalex.org/work/W2247695881> ?p ?o ?g. }
- W2247695881 endingPage "R27" @default.
- W2247695881 startingPage "R15" @default.
- W2247695881 abstract "The gap junction protein connexin43 (CX43) plays a vital role in mammalian spermatogenesis by allowing for direct cytoplasmic communication between neighbouring testicular cells. In addition, different publications suggest that CX43 in Sertoli cells (SC) might be important for blood-testis barrier (BTB) formation and BTB homeostasis. Thus, through the use of the Cre-LoxP recombination system, a transgenic mouse line was developed in which only SC are deficient of the gap junction protein, alpha 1 (Gja1) gene. Gja1 codes for the protein CX43. This transgenic mouse line has been commonly defined as the SC specific CX43 knockout (SCCx43KO) mouse line. Within the seminiferous tubule, SC aid in spermatogenesis by nurturing germ cells and help them to proliferate and mature. Owing to the absence of CX43 within the SC, homozygous KO mice are infertile, have reduced testis size, and mainly exhibit spermatogenesis arrest at the level of spermatogonia, seminiferous tubules containing only SC (SC-only syndrome) and intratubular SC-clusters. Although the SC specific KO of CX43 does not seem to have an adverse effect on BTB integrity, CX43 influences BTB composition as the expression pattern of different BTB proteins (like OCCLUDIN, β-CATENIN, N-CADHERIN, and CLAUDIN11) is altered in mutant males. The supposed roles of CX43 in dynamic BTB regulation, BTB assembly and/or disassembly and its possible interaction with other junctional proteins composing this unique barrier are discussed. Data collectively indicate that CX43 might represent an important regulator of dynamic BTB formation, composition and function." @default.
- W2247695881 created "2016-06-24" @default.
- W2247695881 creator A5025431902 @default.
- W2247695881 creator A5066779213 @default.
- W2247695881 creator A5087346651 @default.
- W2247695881 date "2016-02-01" @default.
- W2247695881 modified "2023-10-16" @default.
- W2247695881 title "Blood–testis barrier and Sertoli cell function: lessons from SCCx43KO mice" @default.
- W2247695881 cites W1496971716 @default.
- W2247695881 cites W1561784350 @default.
- W2247695881 cites W161797718 @default.
- W2247695881 cites W165109855 @default.
- W2247695881 cites W1689027623 @default.
- W2247695881 cites W1967697465 @default.
- W2247695881 cites W1967939956 @default.
- W2247695881 cites W1968394213 @default.
- W2247695881 cites W1971075295 @default.
- W2247695881 cites W1977333131 @default.
- W2247695881 cites W1980047031 @default.
- W2247695881 cites W1981264454 @default.
- W2247695881 cites W1986399507 @default.
- W2247695881 cites W1987082843 @default.
- W2247695881 cites W1987594610 @default.
- W2247695881 cites W1991477082 @default.
- W2247695881 cites W1991504811 @default.
- W2247695881 cites W1993611289 @default.
- W2247695881 cites W1994531230 @default.
- W2247695881 cites W1994832543 @default.
- W2247695881 cites W1997173318 @default.
- W2247695881 cites W2000422049 @default.
- W2247695881 cites W2001016844 @default.
- W2247695881 cites W2003912126 @default.
- W2247695881 cites W2004688423 @default.
- W2247695881 cites W2011560862 @default.
- W2247695881 cites W2015966206 @default.
- W2247695881 cites W2019773494 @default.
- W2247695881 cites W2022581791 @default.
- W2247695881 cites W2029596984 @default.
- W2247695881 cites W2029804435 @default.
- W2247695881 cites W2031853363 @default.
- W2247695881 cites W2034000302 @default.
- W2247695881 cites W2036158416 @default.
- W2247695881 cites W2038214979 @default.
- W2247695881 cites W2038767318 @default.
- W2247695881 cites W2039263897 @default.
- W2247695881 cites W2039926711 @default.
- W2247695881 cites W2041776983 @default.
- W2247695881 cites W2046011724 @default.
- W2247695881 cites W2049693904 @default.
- W2247695881 cites W2053526027 @default.
- W2247695881 cites W2054137257 @default.
- W2247695881 cites W2055061655 @default.
- W2247695881 cites W2055859834 @default.
- W2247695881 cites W2057488707 @default.
- W2247695881 cites W2066428347 @default.
- W2247695881 cites W2066453342 @default.
- W2247695881 cites W2066548544 @default.
- W2247695881 cites W2069035576 @default.
- W2247695881 cites W2069868341 @default.
- W2247695881 cites W2069982236 @default.
- W2247695881 cites W2073080116 @default.
- W2247695881 cites W2077444630 @default.
- W2247695881 cites W2079147888 @default.
- W2247695881 cites W2079482620 @default.
- W2247695881 cites W2079685511 @default.
- W2247695881 cites W2080069132 @default.
- W2247695881 cites W2083687786 @default.
- W2247695881 cites W2085414996 @default.
- W2247695881 cites W2088144323 @default.
- W2247695881 cites W2088892772 @default.
- W2247695881 cites W2089047096 @default.
- W2247695881 cites W2092822317 @default.
- W2247695881 cites W2094679825 @default.
- W2247695881 cites W2097107791 @default.
- W2247695881 cites W2097152977 @default.
- W2247695881 cites W2097890006 @default.
- W2247695881 cites W2098207172 @default.
- W2247695881 cites W2098737213 @default.
- W2247695881 cites W2098872610 @default.
- W2247695881 cites W2102833451 @default.
- W2247695881 cites W2109856100 @default.
- W2247695881 cites W2111124970 @default.
- W2247695881 cites W2117431471 @default.
- W2247695881 cites W2117508313 @default.
- W2247695881 cites W2120075368 @default.
- W2247695881 cites W2120597716 @default.
- W2247695881 cites W2125211869 @default.
- W2247695881 cites W2130879733 @default.
- W2247695881 cites W2131188740 @default.
- W2247695881 cites W2133948311 @default.
- W2247695881 cites W2134207023 @default.
- W2247695881 cites W2137261534 @default.
- W2247695881 cites W2140251609 @default.
- W2247695881 cites W2143612925 @default.
- W2247695881 cites W2144853717 @default.
- W2247695881 cites W2145492059 @default.
- W2247695881 cites W2147810729 @default.
- W2247695881 cites W2153102239 @default.