FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W224770303> ?p ?o ?g. }

• W224770303 endingPage "8" @default.
• W224770303 startingPage "1191" @default.
• W224770303 abstract "The role of the integrin alpha 6 beta 1 in breast carcinoma progression was studied by targeted elimination of this integrin in MDA-MB-435 cells, a human breast carcinoma cell line that is highly metastatic in athymic mice. The strategy used is based on the finding that expression of a cytoplasmic domain deletion mutant of the beta 4-integrin subunit (beta 4-delta CYT) in MDA-MB-435 cells eliminates formation of the alpha 6 beta 1 heterodimer. MDA-MB-435 cells that lacked alpha 6 beta 1 expression (beta 4-delta CYT transfectants) formed tumors in athymic mice that were suppressed in their growth and that exhibited a significant increase in apoptosis in comparison to the control tumors. Unlike the control MDA-MB-435 cells, the beta 4-delta CYT transfectants were unable to establish metastatic foci in the lungs. Also, the control transfectants grew substantially better than the beta 4-delta CYT transfectants in the liver after intrahepatic injection because of extensive apoptosis in the beta 4-delta CYT transfectants. These data suggest that a major function of the alpha 6 beta 1 integrin in breast carcinoma is to facilitate tumorigenesis and promote tumor cell survival in distant organs." @default.
• W224770303 created "2016-06-24" @default.
• W224770303 creator A5010527699 @default.
• W224770303 creator A5023136222 @default.
• W224770303 creator A5047986299 @default.
• W224770303 creator A5055464136 @default.
• W224770303 date "1997-11-01" @default.
• W224770303 modified "2023-10-17" @default.
• W224770303 title "The integrin alpha 6 beta 1 promotes the survival of metastatic human breast carcinoma cells in mice." @default.
• W224770303 cites W1508989149 @default.
• W224770303 cites W1549145380 @default.
• W224770303 cites W1594898068 @default.
• W224770303 cites W1775527315 @default.
• W224770303 cites W1820722629 @default.
• W224770303 cites W1974106745 @default.
• W224770303 cites W1983072511 @default.
• W224770303 cites W1983143581 @default.
• W224770303 cites W1989963027 @default.
• W224770303 cites W2001753204 @default.
• W224770303 cites W2013972195 @default.
• W224770303 cites W2020445671 @default.
• W224770303 cites W2030227542 @default.
• W224770303 cites W2033272151 @default.
• W224770303 cites W2035252564 @default.
• W224770303 cites W2064735316 @default.
• W224770303 cites W2074378720 @default.
• W224770303 cites W2078659715 @default.
• W224770303 cites W2087094729 @default.
• W224770303 cites W2087145616 @default.
• W224770303 cites W2090645687 @default.
• W224770303 cites W2111034197 @default.
• W224770303 cites W2121383876 @default.
• W224770303 cites W2124138369 @default.
• W224770303 cites W2124559417 @default.
• W224770303 cites W2137022580 @default.
• W224770303 cites W2154358347 @default.
• W224770303 cites W2170659857 @default.
• W224770303 cites W2308756229 @default.
• W224770303 cites W1602268739 @default.
• W224770303 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1858063" @default.
• W224770303 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9358743" @default.
• W224770303 hasPublicationYear "1997" @default.
• W224770303 type Work @default.
• W224770303 sameAs 224770303 @default.
• W224770303 citedByCount "39" @default.
• W224770303 countsByYear W2247703032012 @default.
• W224770303 countsByYear W2247703032015 @default.
• W224770303 countsByYear W2247703032016 @default.
• W224770303 countsByYear W2247703032017 @default.
• W224770303 countsByYear W2247703032018 @default.
• W224770303 countsByYear W2247703032020 @default.
• W224770303 crossrefType "journal-article" @default.
• W224770303 hasAuthorship W224770303A5010527699 @default.
• W224770303 hasAuthorship W224770303A5023136222 @default.
• W224770303 hasAuthorship W224770303A5047986299 @default.
• W224770303 hasAuthorship W224770303A5055464136 @default.
• W224770303 hasConcept C121608353 @default.
• W224770303 hasConcept C142724271 @default.
• W224770303 hasConcept C1491633281 @default.
• W224770303 hasConcept C159110408 @default.
• W224770303 hasConcept C190283241 @default.
• W224770303 hasConcept C195687474 @default.
• W224770303 hasConcept C199360897 @default.
• W224770303 hasConcept C2775944032 @default.
• W224770303 hasConcept C2776174256 @default.
• W224770303 hasConcept C2779013556 @default.
• W224770303 hasConcept C3018521938 @default.
• W224770303 hasConcept C41008148 @default.
• W224770303 hasConcept C49453240 @default.
• W224770303 hasConcept C502942594 @default.
• W224770303 hasConcept C530470458 @default.
• W224770303 hasConcept C54009773 @default.
• W224770303 hasConcept C54355233 @default.
• W224770303 hasConcept C55493867 @default.
• W224770303 hasConcept C555283112 @default.
• W224770303 hasConcept C64943373 @default.
• W224770303 hasConcept C71924100 @default.
• W224770303 hasConcept C81885089 @default.
• W224770303 hasConcept C86803240 @default.
• W224770303 hasConceptScore W224770303C121608353 @default.
• W224770303 hasConceptScore W224770303C142724271 @default.
• W224770303 hasConceptScore W224770303C1491633281 @default.
• W224770303 hasConceptScore W224770303C159110408 @default.
• W224770303 hasConceptScore W224770303C190283241 @default.
• W224770303 hasConceptScore W224770303C195687474 @default.
• W224770303 hasConceptScore W224770303C199360897 @default.
• W224770303 hasConceptScore W224770303C2775944032 @default.
• W224770303 hasConceptScore W224770303C2776174256 @default.
• W224770303 hasConceptScore W224770303C2779013556 @default.
• W224770303 hasConceptScore W224770303C3018521938 @default.
• W224770303 hasConceptScore W224770303C41008148 @default.
• W224770303 hasConceptScore W224770303C49453240 @default.
• W224770303 hasConceptScore W224770303C502942594 @default.
• W224770303 hasConceptScore W224770303C530470458 @default.
• W224770303 hasConceptScore W224770303C54009773 @default.
• W224770303 hasConceptScore W224770303C54355233 @default.
• W224770303 hasConceptScore W224770303C55493867 @default.
• W224770303 hasConceptScore W224770303C555283112 @default.

• next