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• W2247705343 abstract "Recent advances in the human cancer genome project have made it increasingly clear that, with few exceptions, the majority of cancer-associated mutations are unique to individual tumor types. One exception to this rule is the tumor suppressor p53. Inactivation of the p53 pathway is one of the most common events in the development of human cancer, which has led to p53 being considered a master tumor suppressor. It is therefore not surprising that the possibility of using p53 as a biomarker for cancer management has attracted considerable attention from both biologists and clinicians. p53-based therapies have also excited academia and industry and will continue to do so. A p53-expressing adenovirus was recently approved as the first gene therapy agent for the routine treatment of patients with head and neck cancer in China. However, despite this success, p53-based therapies remain in their infancy. The wealth of information that we have acquired about p53 in 30 years since its discovery has yet to be translated into routine clinical practice. A full understanding of p53 mutations and the predictive and prognostic value of expression-based diagnostics remains elusive. This is largely due to the heterogeneity of the p53 response to stress signals in vivo , and the diversity of p53 mutations in different tumor types. If we are to develop comprehensive p53-based cancer management methodologies and anticancer therapies in the future, a better understanding of the complexity of p53 biology is essential." @default.
• W2247705343 created "2016-06-24" @default.
• W2247705343 creator A5023977293 @default.
• W2247705343 date "2012-01-01" @default.
• W2247705343 modified "2023-09-24" @default.
• W2247705343 title "p53" @default.
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• W2247705343 doi "https://doi.org/10.1016/b978-0-12-397833-2.00009-1" @default.
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