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• W2247709727 abstract "Although a large proportion of biomolecules involved in spermatozoa-oocyte interaction has been discovered so far, many details of fertilization mechanism remain unknown. Both biochemical and biomechanical components exist in the fertilization process. Mammalian sperm evolved a ZP (zona pelucida) thrust reduction penetration strategy probably in response to the ZP resilient elasticity. Using a biomechanical approach and FEM analysis, local contact stress, ZP deformations during impact and attempt of sperm head penetration relative to different sperm impact angles (SIA) were studied. The sperm-oocyte contact was defined as non-linear frictional contact. A transient structural analysis at 37°C revealed that, from the mechanical standpoint there are SIA that are more favorable for possible ZP penetration due to larger equivalent stress of ZP. An slip-stick resembling effect was identified for almost all examined SIA. The sperm head-ZP contact area increases as SIA decreases. Favorable ZP-stress state for sperm penetration regarding SIA are discussed." @default.
• W2247709727 created "2016-06-24" @default.
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• W2247709727 date "2016-03-01" @default.
• W2247709727 modified "2023-09-27" @default.
• W2247709727 title "The effect of friction and impact angle on the spermatozoa–oocyte local contact dynamics" @default.
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• W2247709727 doi "https://doi.org/10.1016/j.jtbi.2015.12.031" @default.
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