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- W2247759329 abstract "The major role played by endothelial cells in the inactivation of a wide variety of vasoactive and platelet-active compounds is becoming apparent as our knowledge of endothelial biology increases, mainly because of the ability to isolate and culture these cells. Endothelium is currently believed to be responsible for the inactivation of circulating thrombin, bradykinin, several prostaglandins and amines, adenosine and purine nucleotides. In this chapter we shall discuss the metabolism by endothelial cells of three of these molecules: serotonin (5-hydroxytryptamine, 5HT), adenosine and ATP. 5HT is released into the plasma when platelets are activated. It is a powerful vasoconstrictor in most vascular beds, although in some species it is a vasodilator in certain small vessels (1). Virtually all the 5HT in the blood is carried by the platelets in dense storage granules; it is released in common with other granule contents when platelets are stimulated by a variety of agents (e.g. ADP, thrombin, collagen) and is itself a platelet aggregating agent (2)." @default.
- W2247759329 created "2016-06-24" @default.
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- W2247759329 date "1984-01-01" @default.
- W2247759329 modified "2023-09-27" @default.
- W2247759329 title "Metabolism of serotonin and adenosine" @default.
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- W2247759329 doi "https://doi.org/10.1007/978-1-4613-2825-4_33" @default.
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