Matches in SemOpenAlex for { <https://semopenalex.org/work/W2247803565> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2247803565 endingPage "C566" @default.
- W2247803565 startingPage "C561" @default.
- W2247803565 abstract "Primary cultures of airway smooth muscle cells were exposed to histamine, and intracellular free calcium transients were measured by the calcium-sensitive dye fura-2. Stimulation with 100 microM histamine resulted in a rise in intracellular calcium from an unstimulated level of 178 +/- 25 to 497 +/- 154 nM Ca2+ (SE; n = 14) and a return to base-line free calcium concentration within 1 min of stimulation. Pretreatment of cells with the H1 receptor blocker pyrilamine (2.5 microM) abolished the response; however, the calcium transient was not altered by pretreatment with the H2 blocker cimetidine (50 microM), by chelation of external calcium, or by pretreatment with 2 mM Co2+ or 5 microM nifedipine. Activation of protein kinase c by 200 nM phorbol 12-myristate 13-acetate (PMA) resulted in no detectable rise in cytosolic calcium but completely blocked the release of internal calcium by histamine. We conclude that 1) histamine causes a transient rise of cytosolic calcium in airway smooth muscle, 2) the rise in cytosolic calcium is mediated by H1 receptor coupling that triggers release of internal calcium stores, and 3) activation of protein kinase c blocks the histamine-induced release of intracellular calcium." @default.
- W2247803565 created "2016-06-24" @default.
- W2247803565 creator A5039706336 @default.
- W2247803565 creator A5055014981 @default.
- W2247803565 creator A5073879365 @default.
- W2247803565 date "1987-10-01" @default.
- W2247803565 modified "2023-10-17" @default.
- W2247803565 title "Histamine-induced calcium release and phorbol antagonism in cultured airway smooth muscle cells" @default.
- W2247803565 cites W1977731416 @default.
- W2247803565 cites W1978778326 @default.
- W2247803565 cites W1997178403 @default.
- W2247803565 cites W1998609823 @default.
- W2247803565 cites W1999261509 @default.
- W2247803565 cites W2001692359 @default.
- W2247803565 cites W2027154975 @default.
- W2247803565 cites W2030118078 @default.
- W2247803565 cites W2053332583 @default.
- W2247803565 cites W2057333351 @default.
- W2247803565 cites W2058260744 @default.
- W2247803565 cites W2090839129 @default.
- W2247803565 cites W2136835819 @default.
- W2247803565 cites W2137401824 @default.
- W2247803565 cites W2139687001 @default.
- W2247803565 doi "https://doi.org/10.1152/ajpcell.1987.253.4.c561" @default.
- W2247803565 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3661694" @default.
- W2247803565 hasPublicationYear "1987" @default.
- W2247803565 type Work @default.
- W2247803565 sameAs 2247803565 @default.
- W2247803565 citedByCount "109" @default.
- W2247803565 countsByYear W22478035652013 @default.
- W2247803565 countsByYear W22478035652014 @default.
- W2247803565 countsByYear W22478035652015 @default.
- W2247803565 countsByYear W22478035652016 @default.
- W2247803565 countsByYear W22478035652017 @default.
- W2247803565 countsByYear W22478035652019 @default.
- W2247803565 countsByYear W22478035652022 @default.
- W2247803565 crossrefType "journal-article" @default.
- W2247803565 hasAuthorship W2247803565A5039706336 @default.
- W2247803565 hasAuthorship W2247803565A5055014981 @default.
- W2247803565 hasAuthorship W2247803565A5073879365 @default.
- W2247803565 hasConcept C10335311 @default.
- W2247803565 hasConcept C1122143 @default.
- W2247803565 hasConcept C126322002 @default.
- W2247803565 hasConcept C134018914 @default.
- W2247803565 hasConcept C170493617 @default.
- W2247803565 hasConcept C181080969 @default.
- W2247803565 hasConcept C184235292 @default.
- W2247803565 hasConcept C185592680 @default.
- W2247803565 hasConcept C18699975 @default.
- W2247803565 hasConcept C195794163 @default.
- W2247803565 hasConcept C2776885963 @default.
- W2247803565 hasConcept C2779066535 @default.
- W2247803565 hasConcept C2780043322 @default.
- W2247803565 hasConcept C2780356492 @default.
- W2247803565 hasConcept C30979828 @default.
- W2247803565 hasConcept C519063684 @default.
- W2247803565 hasConcept C55493867 @default.
- W2247803565 hasConcept C71924100 @default.
- W2247803565 hasConcept C86803240 @default.
- W2247803565 hasConceptScore W2247803565C10335311 @default.
- W2247803565 hasConceptScore W2247803565C1122143 @default.
- W2247803565 hasConceptScore W2247803565C126322002 @default.
- W2247803565 hasConceptScore W2247803565C134018914 @default.
- W2247803565 hasConceptScore W2247803565C170493617 @default.
- W2247803565 hasConceptScore W2247803565C181080969 @default.
- W2247803565 hasConceptScore W2247803565C184235292 @default.
- W2247803565 hasConceptScore W2247803565C185592680 @default.
- W2247803565 hasConceptScore W2247803565C18699975 @default.
- W2247803565 hasConceptScore W2247803565C195794163 @default.
- W2247803565 hasConceptScore W2247803565C2776885963 @default.
- W2247803565 hasConceptScore W2247803565C2779066535 @default.
- W2247803565 hasConceptScore W2247803565C2780043322 @default.
- W2247803565 hasConceptScore W2247803565C2780356492 @default.
- W2247803565 hasConceptScore W2247803565C30979828 @default.
- W2247803565 hasConceptScore W2247803565C519063684 @default.
- W2247803565 hasConceptScore W2247803565C55493867 @default.
- W2247803565 hasConceptScore W2247803565C71924100 @default.
- W2247803565 hasConceptScore W2247803565C86803240 @default.
- W2247803565 hasIssue "4" @default.
- W2247803565 hasLocation W22478035651 @default.
- W2247803565 hasLocation W22478035652 @default.
- W2247803565 hasOpenAccess W2247803565 @default.
- W2247803565 hasPrimaryLocation W22478035651 @default.
- W2247803565 hasRelatedWork W2003245041 @default.
- W2247803565 hasRelatedWork W2009322402 @default.
- W2247803565 hasRelatedWork W2037529336 @default.
- W2247803565 hasRelatedWork W2073251626 @default.
- W2247803565 hasRelatedWork W2076574426 @default.
- W2247803565 hasRelatedWork W2110261053 @default.
- W2247803565 hasRelatedWork W2247803565 @default.
- W2247803565 hasRelatedWork W2365612635 @default.
- W2247803565 hasRelatedWork W2375114881 @default.
- W2247803565 hasRelatedWork W4231231109 @default.
- W2247803565 hasVolume "253" @default.
- W2247803565 isParatext "false" @default.
- W2247803565 isRetracted "false" @default.
- W2247803565 magId "2247803565" @default.
- W2247803565 workType "article" @default.