Matches in SemOpenAlex for { <https://semopenalex.org/work/W2247809452> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2247809452 endingPage "91" @default.
- W2247809452 startingPage "86" @default.
- W2247809452 abstract "Abstract This investigation sought to determine the role of complement, polymorphonuclear leukocytes, and lysosomal proteases in pseudogout. Acute skin and joint inflammation was induced in rabbits by injection of calcium pyrophosphate dihydrate crystals. When rabbits were depleted of complement with cobra venon before the injection of crystals, the inflammatory response was not affected, whereas leukocyte depletion of the rabbits with vinblastin significantly reduced the inflammatory response. The mixing of trypsin-kallikrein (T-K) inhibitor, an inactivator of acid and neutral lysosomal proteases and kallikrein, with the crystals prior to injection also reduced the inflammatory response. This effect of T-K inhibitor was dose-related. Soybean trypsin inhibitor, a stronger inhibitor of kallikrein than T-K, but with only weak effects upon lysosomal proteases, failed to alter the inflammatory process. Epsilon-amino caproic acid, an inhibitor of neutral but not acid protease, also failed to lessen the inflammation. The studies suggest that calcium phyrophosphate-induced inflammation requires normal levels of circulatory polymorphonuclear leukocytes, but does not depend upon complement and can be inhibited by the T-K inhibitor." @default.
- W2247809452 created "2016-06-24" @default.
- W2247809452 creator A5014510708 @default.
- W2247809452 date "1973-07-01" @default.
- W2247809452 modified "2023-09-23" @default.
- W2247809452 title "Studies on the mechanism of inflammation induced by calcium pyrophosphate crystals." @default.
- W2247809452 cites W1995472052 @default.
- W2247809452 cites W2007434222 @default.
- W2247809452 cites W2015697122 @default.
- W2247809452 cites W2043850708 @default.
- W2247809452 cites W2049499903 @default.
- W2247809452 cites W2060419618 @default.
- W2247809452 cites W2066173259 @default.
- W2247809452 cites W2081462859 @default.
- W2247809452 cites W2112007557 @default.
- W2247809452 cites W2340199679 @default.
- W2247809452 cites W2396312390 @default.
- W2247809452 cites W2412034049 @default.
- W2247809452 cites W2413351169 @default.
- W2247809452 cites W2428349926 @default.
- W2247809452 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4352266" @default.
- W2247809452 hasPublicationYear "1973" @default.
- W2247809452 type Work @default.
- W2247809452 sameAs 2247809452 @default.
- W2247809452 citedByCount "5" @default.
- W2247809452 crossrefType "journal-article" @default.
- W2247809452 hasAuthorship W2247809452A5014510708 @default.
- W2247809452 hasConcept C141814087 @default.
- W2247809452 hasConcept C178790620 @default.
- W2247809452 hasConcept C181199279 @default.
- W2247809452 hasConcept C182220744 @default.
- W2247809452 hasConcept C185592680 @default.
- W2247809452 hasConcept C203014093 @default.
- W2247809452 hasConcept C2776351012 @default.
- W2247809452 hasConcept C2776914184 @default.
- W2247809452 hasConcept C2780340462 @default.
- W2247809452 hasConcept C519063684 @default.
- W2247809452 hasConcept C52853521 @default.
- W2247809452 hasConcept C55493867 @default.
- W2247809452 hasConcept C86803240 @default.
- W2247809452 hasConceptScore W2247809452C141814087 @default.
- W2247809452 hasConceptScore W2247809452C178790620 @default.
- W2247809452 hasConceptScore W2247809452C181199279 @default.
- W2247809452 hasConceptScore W2247809452C182220744 @default.
- W2247809452 hasConceptScore W2247809452C185592680 @default.
- W2247809452 hasConceptScore W2247809452C203014093 @default.
- W2247809452 hasConceptScore W2247809452C2776351012 @default.
- W2247809452 hasConceptScore W2247809452C2776914184 @default.
- W2247809452 hasConceptScore W2247809452C2780340462 @default.
- W2247809452 hasConceptScore W2247809452C519063684 @default.
- W2247809452 hasConceptScore W2247809452C52853521 @default.
- W2247809452 hasConceptScore W2247809452C55493867 @default.
- W2247809452 hasConceptScore W2247809452C86803240 @default.
- W2247809452 hasIssue "1" @default.
- W2247809452 hasLocation W22478094521 @default.
- W2247809452 hasOpenAccess W2247809452 @default.
- W2247809452 hasPrimaryLocation W22478094521 @default.
- W2247809452 hasRelatedWork W145587086 @default.
- W2247809452 hasRelatedWork W2049656997 @default.
- W2247809452 hasRelatedWork W2061570852 @default.
- W2247809452 hasRelatedWork W2143454710 @default.
- W2247809452 hasRelatedWork W2149908582 @default.
- W2247809452 hasRelatedWork W2298482709 @default.
- W2247809452 hasRelatedWork W2338853042 @default.
- W2247809452 hasRelatedWork W2418896826 @default.
- W2247809452 hasRelatedWork W3008664533 @default.
- W2247809452 hasRelatedWork W3015489682 @default.
- W2247809452 hasVolume "82" @default.
- W2247809452 isParatext "false" @default.
- W2247809452 isRetracted "false" @default.
- W2247809452 magId "2247809452" @default.
- W2247809452 workType "article" @default.