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• W2247813215 abstract "Chlamydiae are Gram-negative intracellular obligate bacterial pathogens causing major health problems. Chlamydia trachomatis is the most common agent of bacterial urogenital infections responsible for cervicitis, ectopic pregnancy, tubal infertility, and pelvic inflammatory disease (PID) in women. Other than genital complications, C. trachomatis is a major cause of trachoma, the leading cause of preventable blindness in humans. Chlamydia pneumoniae causes respiratory disease and has been associated with asthma and atherosclerosis. The persistent infection of Chlamydia modulates the immune system of the host for its own survival, which remains a problem, and often leads to immunopathogenesis. The chronic infections not only exhibit highly unusual forms of intracellular Chlamydiae, but also display induction of Chlamydial Heat Shock Protein (cHSP) 60 and reduction in the expression of other chlamydial antigens. cHSP60 has been identified as strong immunodominant antigen and target of both humoral and cell-mediated immunity (CMI) responses. The cHSP60 released from the Chlamydia infected cells is capable of eliciting potent localized proinflammatory immune response resulting in the production of antibodies against cHSP60 and other inflammatory mediators which makes them one of the major virulence determinants of Chlamydiae. It is established that Chlamydia has three genes encoding chaperonin 60 paralogues, however all of our information on the chaperonin 60 protein of Chlamydia comes from chaperonin 60.1. This chapter is focused on the moonlighting action of the chlamydial chaperonin 60 protein, cHSP60.1." @default.
• W2247813215 created "2016-06-24" @default.
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• W2247813215 date "2013-01-01" @default.
• W2247813215 modified "2023-09-23" @default.
• W2247813215 title "Chaperonin 60.1 of the Chlamydiae (cHSP60) as a Major Virulence Determinant" @default.
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• W2247813215 doi "https://doi.org/10.1007/978-94-007-6787-4_10" @default.
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