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- W2247874078 abstract "Thiols are among the most frequently used functional groups in the field of bioconjugation. While there exists a variety of heterobifunctional reagents that allow for coupling thiols to other functions (e.g., amines, carboxylic acids), there is no specific reagent for creating heteroconjugates using two different thiols. In response to the ever-increasing demand for bioconjugation tools, we have developed p-(maleimide)-phenylpropionitrile (MAPN)—an efficient reagent for kinetically resolved thiol-to-thiol coupling. In a comparative study with its closest commercially available analogue, p-phenylenedimaleimide, MAPN has shown substantial advantages for the preparation of thiol–thiol heteroconjugates. Namely, an antibody–drug conjugate (ADC) with mertansine (DM1), conjugated to the cysteine residues of Trastuzumab, was prepared for the first time." @default.
- W2247874078 created "2016-06-24" @default.
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- W2247874078 date "2015-09-03" @default.
- W2247874078 modified "2023-10-18" @default.
- W2247874078 title "MAPN: First-in-Class Reagent for Kinetically Resolved Thiol-to-Thiol Conjugation" @default.
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- W2247874078 doi "https://doi.org/10.1021/acs.bioconjchem.5b00440" @default.
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