Matches in SemOpenAlex for { <https://semopenalex.org/work/W2247938431> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2247938431 endingPage "57" @default.
- W2247938431 startingPage "346" @default.
- W2247938431 abstract "1. A method is described for the estimation of phenylbutazone in biological fluids and tissues.2. Phenylbutazone is rapidly and completely absorbed from the gastrointestinal tract of man. Intramuscular absorption, on the other hand, is relatively slow, because of localization of the drug at the site of the injection.3. Phenylbutazone at therapeutic concentrations is highly bound to plasma proteins. About one-third of a single dose of the drug is localized in plasma.4. The drug is almost completely metabolized in the body. After discontinuance of dosage, the rate of biotransformation in man is slow, averaging about 20 per cent per day, but varies considerably in different subjects. Subjects with Laennec's cirrhosis of the liver metabolize the drug as readily as normal subjects.5. Plasma levels of phenylbutazone are not proportional to dosage. Plasma levels achieved on doses of 1600 mgm. per day are only a few per cent higher than those obtained on doses of 800 mgm. per day. On both dosage regimens, absorption is complete and urinary excretion of the drug is negligible.6. Different species vary markedly in the rates at which they metabolize phenylbutazone. The biologic half-life of the drug is about 72 hours in man, 6 hours in dog and rat, 5 hours in guinea pig, and 3 hours in rabbit." @default.
- W2247938431 created "2016-06-24" @default.
- W2247938431 creator A5006534967 @default.
- W2247938431 creator A5040325013 @default.
- W2247938431 creator A5059671306 @default.
- W2247938431 creator A5061692884 @default.
- W2247938431 creator A5081100524 @default.
- W2247938431 creator A5086261196 @default.
- W2247938431 date "1953-11-01" @default.
- W2247938431 modified "2023-10-10" @default.
- W2247938431 title "The physiological disposition of phenylbutazone (butazolidin) in man and a method for its estimation in biological material." @default.
- W2247938431 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/13109696" @default.
- W2247938431 hasPublicationYear "1953" @default.
- W2247938431 type Work @default.
- W2247938431 sameAs 2247938431 @default.
- W2247938431 citedByCount "103" @default.
- W2247938431 countsByYear W22479384312018 @default.
- W2247938431 countsByYear W22479384312022 @default.
- W2247938431 crossrefType "journal-article" @default.
- W2247938431 hasAuthorship W2247938431A5006534967 @default.
- W2247938431 hasAuthorship W2247938431A5040325013 @default.
- W2247938431 hasAuthorship W2247938431A5059671306 @default.
- W2247938431 hasAuthorship W2247938431A5061692884 @default.
- W2247938431 hasAuthorship W2247938431A5081100524 @default.
- W2247938431 hasAuthorship W2247938431A5086261196 @default.
- W2247938431 hasConcept C10146269 @default.
- W2247938431 hasConcept C112705442 @default.
- W2247938431 hasConcept C121332964 @default.
- W2247938431 hasConcept C125287762 @default.
- W2247938431 hasConcept C126322002 @default.
- W2247938431 hasConcept C185592680 @default.
- W2247938431 hasConcept C24890656 @default.
- W2247938431 hasConcept C2775844104 @default.
- W2247938431 hasConcept C2777214474 @default.
- W2247938431 hasConcept C2780035454 @default.
- W2247938431 hasConcept C3941253 @default.
- W2247938431 hasConcept C55493867 @default.
- W2247938431 hasConcept C71924100 @default.
- W2247938431 hasConcept C98274493 @default.
- W2247938431 hasConceptScore W2247938431C10146269 @default.
- W2247938431 hasConceptScore W2247938431C112705442 @default.
- W2247938431 hasConceptScore W2247938431C121332964 @default.
- W2247938431 hasConceptScore W2247938431C125287762 @default.
- W2247938431 hasConceptScore W2247938431C126322002 @default.
- W2247938431 hasConceptScore W2247938431C185592680 @default.
- W2247938431 hasConceptScore W2247938431C24890656 @default.
- W2247938431 hasConceptScore W2247938431C2775844104 @default.
- W2247938431 hasConceptScore W2247938431C2777214474 @default.
- W2247938431 hasConceptScore W2247938431C2780035454 @default.
- W2247938431 hasConceptScore W2247938431C3941253 @default.
- W2247938431 hasConceptScore W2247938431C55493867 @default.
- W2247938431 hasConceptScore W2247938431C71924100 @default.
- W2247938431 hasConceptScore W2247938431C98274493 @default.
- W2247938431 hasIssue "3" @default.
- W2247938431 hasLocation W22479384311 @default.
- W2247938431 hasOpenAccess W2247938431 @default.
- W2247938431 hasPrimaryLocation W22479384311 @default.
- W2247938431 hasRelatedWork W1507819824 @default.
- W2247938431 hasRelatedWork W1986187172 @default.
- W2247938431 hasRelatedWork W202060702 @default.
- W2247938431 hasRelatedWork W2035434638 @default.
- W2247938431 hasRelatedWork W2054683562 @default.
- W2247938431 hasRelatedWork W2131557988 @default.
- W2247938431 hasRelatedWork W2257766721 @default.
- W2247938431 hasRelatedWork W2428910357 @default.
- W2247938431 hasRelatedWork W4251033333 @default.
- W2247938431 hasRelatedWork W65313408 @default.
- W2247938431 hasVolume "109" @default.
- W2247938431 isParatext "false" @default.
- W2247938431 isRetracted "false" @default.
- W2247938431 magId "2247938431" @default.
- W2247938431 workType "article" @default.