FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2247996556> ?p ?o ?g. }

• W2247996556 abstract "Estrogen replacement therapy (ERT) has been associated with favorable effects on risk factors for atherosclerosis. In observational studies ERT was also suggested to reduce the risk of cardiovascular disease in postmenopausal women, but the cardioprotective role of estrogen has been challenged after negative results in randomized trials. However, the mechanisms of estrogen action in atherosclerosis development are only partially known. In order to investigate the regulation of plasma low-density lipoprotein (LDL) cholesterol in postmenopausal women and the effects of ERT on cholesterol and glucose metabolism and blood pressure, 79 hysterectomized, non-diabetic postmenopausal women were randomized in a doubleblind, double-dummy study to receive either peroral estradiol valerate (2 mg/day) or transdermal 17βestradiol gel (1 mg estradiol/day) for six months. At baseline the level of LDL cholesterol was related to body mass index, the fractional catabolic rate (FCR) and the production of LDL apolipoprotein B (apo B), but not to cholesterol absorption efficiency. Both peroral and transdermal ERT decreased plasma total and LDL cholesterol, while high-density lipoprotein cholesterol and triglycerides increased only in the peroral group. The LDLlowering response was related to changes in estrogen levels, which presumably enhance LDL receptor activity shown as an increase in FCR for LDL apo B. In contrast, the determined genetic factors, apo E phenotype, EcoRI and XbaI polymorphisms of the apo B gene and polymorphism of 7α-hydroxylase gene, were not significant in regulation of LDL cholesterol, neither did they modify the response of ERT in these postmenopausal women. Similar outcomes were observed with both peroral and transdermal ERT as regards glucose metabolism and blood pressure. The overall effect of ERT on glucose tolerance was found to be neutral. Blood pressure decreased among non-hypertensive subjects on both estrogens, which could be related, at least in part, to the alterations in vasoactive peptides. The data of the present study suggest an overall favorable effect of both peroral and transdermal estrogen on common cardiovascular risk factors. However, the clinical significance of these findings in the prevention of cardiovascular diseases needs to be proven in long-term, randomized trials." @default.
• W2247996556 created "2016-06-24" @default.
• W2247996556 creator A5088844491 @default.
• W2247996556 date "2003-01-01" @default.
• W2247996556 modified "2023-09-27" @default.
• W2247996556 title "Effect of estrogen replacement therapy on metabolic risk factors for cardiovascular diseases in hysterectomized postmenopausal women" @default.
• W2247996556 cites W132700134 @default.
• W2247996556 cites W145637426 @default.
• W2247996556 cites W1555140191 @default.
• W2247996556 cites W1582396128 @default.
• W2247996556 cites W1593442063 @default.
• W2247996556 cites W17105541 @default.
• W2247996556 cites W1775749144 @default.
• W2247996556 cites W1823018609 @default.
• W2247996556 cites W1841210688 @default.
• W2247996556 cites W1849654724 @default.
• W2247996556 cites W1904672210 @default.
• W2247996556 cites W1911477298 @default.
• W2247996556 cites W1928327895 @default.
• W2247996556 cites W1932760451 @default.
• W2247996556 cites W1963521889 @default.
• W2247996556 cites W1963677170 @default.
• W2247996556 cites W1964355961 @default.
• W2247996556 cites W1966701899 @default.
• W2247996556 cites W1966837680 @default.
• W2247996556 cites W1967181271 @default.
• W2247996556 cites W1972453512 @default.
• W2247996556 cites W1972688206 @default.
• W2247996556 cites W1972718093 @default.
• W2247996556 cites W1974580748 @default.
• W2247996556 cites W1976113748 @default.
• W2247996556 cites W19779768 @default.
• W2247996556 cites W1978092733 @default.
• W2247996556 cites W1979492130 @default.
• W2247996556 cites W1980646117 @default.
• W2247996556 cites W1980835899 @default.
• W2247996556 cites W1980866997 @default.
• W2247996556 cites W1981027567 @default.
• W2247996556 cites W1981819721 @default.
• W2247996556 cites W1981922048 @default.
• W2247996556 cites W1982563188 @default.
• W2247996556 cites W1983941964 @default.
• W2247996556 cites W1984368177 @default.
• W2247996556 cites W1984634515 @default.
• W2247996556 cites W1985992498 @default.
• W2247996556 cites W1986197226 @default.
• W2247996556 cites W1988197532 @default.
• W2247996556 cites W1990031103 @default.
• W2247996556 cites W1991405020 @default.
• W2247996556 cites W1992547735 @default.
• W2247996556 cites W1993110028 @default.
• W2247996556 cites W1993137458 @default.
• W2247996556 cites W1994050458 @default.
• W2247996556 cites W1994941307 @default.
• W2247996556 cites W1995260848 @default.
• W2247996556 cites W1995780952 @default.
• W2247996556 cites W1995916011 @default.
• W2247996556 cites W1997512708 @default.
• W2247996556 cites W1997967334 @default.
• W2247996556 cites W1998000672 @default.
• W2247996556 cites W1999388462 @default.
• W2247996556 cites W2000137056 @default.
• W2247996556 cites W2001193462 @default.
• W2247996556 cites W2002120032 @default.
• W2247996556 cites W2003809952 @default.
• W2247996556 cites W2004044750 @default.
• W2247996556 cites W2006096652 @default.
• W2247996556 cites W2006867892 @default.
• W2247996556 cites W2006923783 @default.
• W2247996556 cites W2007862652 @default.
• W2247996556 cites W2008660251 @default.
• W2247996556 cites W2010864473 @default.
• W2247996556 cites W2011840536 @default.
• W2247996556 cites W2012816393 @default.
• W2247996556 cites W2012885729 @default.
• W2247996556 cites W2012952446 @default.
• W2247996556 cites W2012974823 @default.
• W2247996556 cites W2014236193 @default.
• W2247996556 cites W2014420470 @default.
• W2247996556 cites W2016073431 @default.
• W2247996556 cites W2016429718 @default.
• W2247996556 cites W2017458937 @default.
• W2247996556 cites W2018136180 @default.
• W2247996556 cites W2018312028 @default.
• W2247996556 cites W2018548117 @default.
• W2247996556 cites W2018611651 @default.
• W2247996556 cites W2018655550 @default.
• W2247996556 cites W2020967365 @default.
• W2247996556 cites W2024075987 @default.
• W2247996556 cites W202473721 @default.
• W2247996556 cites W2025435578 @default.
• W2247996556 cites W2025901473 @default.
• W2247996556 cites W2026845568 @default.
• W2247996556 cites W2027551831 @default.
• W2247996556 cites W2028547764 @default.
• W2247996556 cites W2030158759 @default.
• W2247996556 cites W2030395931 @default.
• W2247996556 cites W2031216942 @default.
• W2247996556 cites W2032694580 @default.
• W2247996556 cites W2033756945 @default.

• next