Matches in SemOpenAlex for { <https://semopenalex.org/work/W2248218215> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2248218215 endingPage "357" @default.
- W2248218215 startingPage "351" @default.
- W2248218215 abstract "Plant constituents such as terpenes are major constituents of the essential oil in Eucalyptus sp. 1,8-Cineole and p-cymene (Terpenes present in high amounts in Eucalyptus leaves) are potential substrates for the CYP family of enzymes. We have investigated tolbutamide hydroxylase as a probe substrate reaction in both koala and terpene pretreated and control brushtail possum liver microsomes and examined inhibition of this reaction by Eucalyptus terpenes. The specific activity determined for tolbutamide hydroxylase in the terpene treated brushtails was significantly higher than that for the control animals (1865+/-334 nmol/mg microsomal protein per min versus 895+/-27 nmol/mg microsomal protein per min). The activity determined in koala microsomes was 8159+/-370 nmol/mg microsomal protein per min. Vmax values and Km values for the terpene treated possum, control, possum and koala were 1932-2225 nmol/mg microsomal protein per min and 0.80 0.81 mM; 1406-1484 nmol/mg microsomal protein per min and 0.87-0.92 mM and 5895-6403 nmol/mg microsomal protein per min and 0.067-0.071 mM, respectively. Terpenes were examined as potential inhibitors of tolbutamide hydroxylase activity. 1,8-Cineole was found to be a competitive inhibitor for the enzyme responsible for tolbutamide hydroxylation (Ki 15 microM) in the possum. In koala liver microsomes stimulation of tolbutamide hydroxylase activity was observed when concentrations of cineole were increased. Therefore, although inhibition was observed, the type of inhibition could not be determined." @default.
- W2248218215 created "2016-06-24" @default.
- W2248218215 creator A5051351126 @default.
- W2248218215 creator A5054245804 @default.
- W2248218215 creator A5055670639 @default.
- W2248218215 creator A5089085766 @default.
- W2248218215 date "2000-12-01" @default.
- W2248218215 modified "2023-10-12" @default.
- W2248218215 title "Characterisation of tolbutamide hydroxylase activity in the common brushtail possum, (Trichosurus vulpecula) and koala (Phascolarctos cinereus): inhibition by the Eucalyptus terpene 1,8-cineole" @default.
- W2248218215 cites W1746765074 @default.
- W2248218215 cites W1967425934 @default.
- W2248218215 cites W1983238404 @default.
- W2248218215 cites W2008984280 @default.
- W2248218215 cites W2016756631 @default.
- W2248218215 cites W2028603080 @default.
- W2248218215 cites W2044695596 @default.
- W2248218215 cites W2053475332 @default.
- W2248218215 cites W2056270838 @default.
- W2248218215 cites W2068830423 @default.
- W2248218215 cites W2091023332 @default.
- W2248218215 cites W2092702393 @default.
- W2248218215 cites W2152686416 @default.
- W2248218215 cites W2163891284 @default.
- W2248218215 doi "https://doi.org/10.1016/s0742-8413(00)00163-8" @default.
- W2248218215 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11246507" @default.
- W2248218215 hasPublicationYear "2000" @default.
- W2248218215 type Work @default.
- W2248218215 sameAs 2248218215 @default.
- W2248218215 citedByCount "9" @default.
- W2248218215 countsByYear W22482182152015 @default.
- W2248218215 countsByYear W22482182152016 @default.
- W2248218215 countsByYear W22482182152017 @default.
- W2248218215 crossrefType "journal-article" @default.
- W2248218215 hasAuthorship W2248218215A5051351126 @default.
- W2248218215 hasAuthorship W2248218215A5054245804 @default.
- W2248218215 hasAuthorship W2248218215A5055670639 @default.
- W2248218215 hasAuthorship W2248218215A5089085766 @default.
- W2248218215 hasConcept C181199279 @default.
- W2248218215 hasConcept C185592680 @default.
- W2248218215 hasConcept C44937612 @default.
- W2248218215 hasConcept C526171541 @default.
- W2248218215 hasConcept C55493867 @default.
- W2248218215 hasConcept C86803240 @default.
- W2248218215 hasConcept C87644729 @default.
- W2248218215 hasConceptScore W2248218215C181199279 @default.
- W2248218215 hasConceptScore W2248218215C185592680 @default.
- W2248218215 hasConceptScore W2248218215C44937612 @default.
- W2248218215 hasConceptScore W2248218215C526171541 @default.
- W2248218215 hasConceptScore W2248218215C55493867 @default.
- W2248218215 hasConceptScore W2248218215C86803240 @default.
- W2248218215 hasConceptScore W2248218215C87644729 @default.
- W2248218215 hasIssue "3" @default.
- W2248218215 hasLocation W22482182151 @default.
- W2248218215 hasLocation W22482182152 @default.
- W2248218215 hasOpenAccess W2248218215 @default.
- W2248218215 hasPrimaryLocation W22482182151 @default.
- W2248218215 hasRelatedWork W1977200340 @default.
- W2248218215 hasRelatedWork W2009067244 @default.
- W2248218215 hasRelatedWork W2010372900 @default.
- W2248218215 hasRelatedWork W2035768922 @default.
- W2248218215 hasRelatedWork W2042153386 @default.
- W2248218215 hasRelatedWork W2065354896 @default.
- W2248218215 hasRelatedWork W2129133150 @default.
- W2248218215 hasRelatedWork W2326549699 @default.
- W2248218215 hasRelatedWork W2473315520 @default.
- W2248218215 hasRelatedWork W3021177496 @default.
- W2248218215 hasVolume "127" @default.
- W2248218215 isParatext "false" @default.
- W2248218215 isRetracted "false" @default.
- W2248218215 magId "2248218215" @default.
- W2248218215 workType "article" @default.