Matches in SemOpenAlex for { <https://semopenalex.org/work/W2248561048> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2248561048 endingPage "133" @default.
- W2248561048 startingPage "126" @default.
- W2248561048 abstract "A simple and cost effective spectrophotometric method is described for the determination of Imipenem (IMP) in pure and pharmaceutical formulations. The method is based on the formation of dark yellow colored chromogen when the drug reacts with 1,2 naphtho quinone 4-sulphonic acid sodium salt (NQS) reagent in alkalline medium. The method involves the addition of excess NQS of known concentration in the presence of 2.0 mL NaOH and the unreacted NQS was determined by the measurement of the λ max 449 nm, which was found to be the most suitable of several tests. This method was applied for the determination of drug contents in pharmaceutical formulations and enabled the determination of the drug in microgram quantities (0.5 to 3.0 mL). No interference is observed from excipients and the validity of the method was tested against reference method. The colored species has an absorption maximum at 449 nm for IMP (Method A) and obeys beer’s law in the concentration range 0.02 – 0.12 mg/mL of IMP. The apparent molar absorptivity is 0.0190 and sandell’s sensitivity is 7x10 -4 . The slope is 0.2284 ± 0.0118 and intercept of the equation of the regression line is 0.04971 ± 0.02144 . The optimum experimental parameters for the reaction have been studied and the validity of the described procedure was assessed. Statistical analysis of the results has been carried out revealing high accuracy and good precision. The proposed method was successfully applied for the determination of IMP in pharmaceutical formulations." @default.
- W2248561048 created "2016-06-24" @default.
- W2248561048 creator A5005948527 @default.
- W2248561048 creator A5006455037 @default.
- W2248561048 creator A5041477838 @default.
- W2248561048 creator A5062243827 @default.
- W2248561048 date "2014-01-31" @default.
- W2248561048 modified "2023-09-23" @default.
- W2248561048 title "Spectrophotometric Determination of Imipenem in Bulk and Injection Formulations by 1,2 Naphtho Quinone 4-Sulphonic Acid (NQS) Reagent" @default.
- W2248561048 hasPublicationYear "2014" @default.
- W2248561048 type Work @default.
- W2248561048 sameAs 2248561048 @default.
- W2248561048 citedByCount "2" @default.
- W2248561048 countsByYear W22485610482019 @default.
- W2248561048 countsByYear W22485610482020 @default.
- W2248561048 crossrefType "journal-article" @default.
- W2248561048 hasAuthorship W2248561048A5005948527 @default.
- W2248561048 hasAuthorship W2248561048A5006455037 @default.
- W2248561048 hasAuthorship W2248561048A5041477838 @default.
- W2248561048 hasAuthorship W2248561048A5062243827 @default.
- W2248561048 hasConcept C106186310 @default.
- W2248561048 hasConcept C120665830 @default.
- W2248561048 hasConcept C121332964 @default.
- W2248561048 hasConcept C178790620 @default.
- W2248561048 hasConcept C185592680 @default.
- W2248561048 hasConcept C2780343419 @default.
- W2248561048 hasConcept C2780643102 @default.
- W2248561048 hasConcept C40875361 @default.
- W2248561048 hasConcept C43617362 @default.
- W2248561048 hasConcept C71240020 @default.
- W2248561048 hasConcept C76046532 @default.
- W2248561048 hasConceptScore W2248561048C106186310 @default.
- W2248561048 hasConceptScore W2248561048C120665830 @default.
- W2248561048 hasConceptScore W2248561048C121332964 @default.
- W2248561048 hasConceptScore W2248561048C178790620 @default.
- W2248561048 hasConceptScore W2248561048C185592680 @default.
- W2248561048 hasConceptScore W2248561048C2780343419 @default.
- W2248561048 hasConceptScore W2248561048C2780643102 @default.
- W2248561048 hasConceptScore W2248561048C40875361 @default.
- W2248561048 hasConceptScore W2248561048C43617362 @default.
- W2248561048 hasConceptScore W2248561048C71240020 @default.
- W2248561048 hasConceptScore W2248561048C76046532 @default.
- W2248561048 hasIssue "1" @default.
- W2248561048 hasOpenAccess W2248561048 @default.
- W2248561048 hasRelatedWork W2028070482 @default.
- W2248561048 hasRelatedWork W2039211561 @default.
- W2248561048 hasRelatedWork W2042584187 @default.
- W2248561048 hasRelatedWork W2053364756 @default.
- W2248561048 hasRelatedWork W2056298058 @default.
- W2248561048 hasRelatedWork W2093920359 @default.
- W2248561048 hasRelatedWork W2137754020 @default.
- W2248561048 hasRelatedWork W2148329399 @default.
- W2248561048 hasRelatedWork W2156613868 @default.
- W2248561048 hasRelatedWork W2183739948 @default.
- W2248561048 hasRelatedWork W2291681403 @default.
- W2248561048 hasRelatedWork W2309854713 @default.
- W2248561048 hasRelatedWork W2600446505 @default.
- W2248561048 hasRelatedWork W2600466744 @default.
- W2248561048 hasRelatedWork W2620863742 @default.
- W2248561048 hasRelatedWork W2738511212 @default.
- W2248561048 hasRelatedWork W391241260 @default.
- W2248561048 hasRelatedWork W128720570 @default.
- W2248561048 hasRelatedWork W2188136820 @default.
- W2248561048 hasRelatedWork W2582720876 @default.
- W2248561048 hasVolume "2" @default.
- W2248561048 isParatext "false" @default.
- W2248561048 isRetracted "false" @default.
- W2248561048 magId "2248561048" @default.
- W2248561048 workType "article" @default.