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• W2248866390 abstract "The introduction in 1952 of isoniazid established the standard treatment of streptomycin, isoniazid and either thiacetazone or para-aminosalicylic acid for pulmonary tuberculosis. To achieve good results, patients had to take treatment for 18 or even 24 months under supervision. By 1970 a move towards short-course chemotherapy was made, in part due to experimental work in mice at the Pasteur Institute (Paris) and in part to experiments in Professor Denny Mitchison's unit at the Hammersmith Hospital, along with the advent of rifampicin and reappraisal of pyrazinamide. Finally, a series of large controlled clinical trials were carried out by the MRC in East and Central Africa, India, Singapore, Hong Kong and elsewhere. The trials showed that a remarkable and quite unpredictable simplification of treatment could be made with a cost-benefit of major importance.Chaired by Dr David Girling this Witness Seminar brought together a group of experts who were involved in some of the major developments in the treatment of tuberculosis and included: Dr Joseph Angel, Dr Ian Campbell, Sir Iain Chalmers, Dr Kenneth Citron, Sir John Crofton, Professor Janet Darbyshire, Professor Alan Glynn, Dr Tony Jenkins, Dr Amina Jindani, Dr Jeanette Meadway, Professor Dennis Mitchison, Dr John Moore-Gillon, Professor Andrew Nunn, Professor Peter Ormerod and Dr Knut Ovreberg. Mrs Gaye Fox attended on behalf of Professor Wallace Fox." @default.
• W2248866390 created "2016-06-24" @default.
• W2248866390 creator A5019219408 @default.
• W2248866390 creator A5060946102 @default.
• W2248866390 date "2005-07-30" @default.
• W2248866390 modified "2023-09-28" @default.
• W2248866390 title "Short-Course Chemotherapy for Tuberculosis" @default.
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