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- W2249251567 abstract "Objective:To explore the effect of Naoshuning on the protein expression of Matrix metalloproteinases(MMPs) in experimental injuried brain tissue of rats. Methods:Immunohistochemistry was used to determine the changes of protein expression of MMPs. Brain tissue water content,permeability and ultramicrostructure of blood-brain barrier(BBB) were also observed. Results:Compared with the sham group,the brain tissue water and EB content of injured side and the level of MMP-2 and MMP-9 protein expression in brain tissue around contusion in model group increased obviously(all P0.01) . The electron microscope result indicated that BBB was evidently damaged.In Naoshuning group,brain tissue water and EB content and the expression of MMP-2 and MMP-9 were obviously lower than those of the model group at each time point(P0.05～0.01) . The ultramicrostructure changes could be relieved by Naoshuning. Conclusion:This study indicates that Chinese medicine Naoshuning could alleviate cerebral edema via protecting BBB,which might be realized by the inhibition on expression of MMP-2 and MMP-9 protein." @default.
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- W2249251567 date "2009-01-01" @default.
- W2249251567 modified "2023-09-24" @default.
- W2249251567 title "Effect of Naoshuning on MMP-2/9 protein expression in traumatic brain injury rats" @default.
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