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• W2249360116 abstract "The envolvimentonto central nervous system with meningitis has traditionally been reported in both infections C. and C. neoformans gattii, with or without clinical or radiological signs of lung injury. Almost all forms disseminated by strains of C. neoformans occurred in immunocompromised individuals, except in a few cases with predisposing factors, suggesting the existence of some escape mechanisms. In contrast cryptococcosis by C. gattii, often affects individuals without identifiable immune injury, and commonly shows pulmonary lesions and central nervous system associated with meningitis. As the mechanisms involved in the early stages of pulmonary infection by Cryptococcus species are still little known, were tracked separately the process of internalization of two strains of C. and C. neoformans gattii, the lungs of immunocompetent mice, describing and comparing this penetration possible differences. Materials and Methods: Swiss Webster mice were intratracheally instilled with: a) 10 5 yeasts of C. 50μL neoformas in saline (30 animals), b) 10 5 yeasts C. gattii in 50μL of saline (30 animals), or c) 50μL of saline without yeast Cryptococcus (10 animals). After instillation, the abdomen of the mice was compressed and released to promote a deep inhalation. Animals were sacrificed 2, 12, 24, 48 and 72h after instilacao.A each period the animals were euthanized by intraperitoneal injection of 1.0 mL of 2.5% sodium pentobarbital. Results and Discussion: The histopathology of the lungs of mice infected with C. or C. neoformans gattii revealed important peculiarities. One of the main differences is the early expression of capsule polysaccharide by C. in comparison to C. neoformans gattii. Because of their expression of early polysaccharide capsule, C. neoformans is larger in size, which may contribute to their escape from host defense mechanisms, and greater persistence in the respiratory tract. This escape mechanism and the consequent difficulty for the diffusion result in significant local inflammatory reaction accompanied by sprouting early. Conclusions: Lung invasion and the mechanisms of dissemination of Cryptococcus in the respiratory tract in the early stages of experimental infection did not directly dependent on the participation of mononuclear cells and neutrophilic. This process took place, the physical interaction between fungi and respiratory epithelium, but the mechanisms are unknown intrinsic" @default.
• W2249360116 created "2016-06-24" @default.
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• W2249360116 date "2008-01-01" @default.
• W2249360116 modified "2023-09-27" @default.
• W2249360116 title "Alterações histopatológicas iniciais pulmonares na infecção aguda experimental de camundongos Swiss webster imunocompetentes por Cryptococcus neoformans e C. gatti." @default.
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