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- W2249387683 abstract "Objective To reproduce an animal model of myocardium hyperkalemia and to relieve its symptoms with calcium chloride(CaCl2) with the purpose of observing the effect of hyperkalemia on electrocardiogram Ⅱ(ECGⅡ).Methods Fifty toads(either gender) were assigned into two groups,i.e.experiment group and control group.Animals in experiment group were injected with 0.3ml of 0.2% potassium chloride(KCl) via abdominal vein to reproduce hyperkalemia model,while those in control group were injected same amount of 0.9% sodium chloride(NaCl),then ECG Ⅱ was synchronously recorded.Two minutes later,animals in experiment group were injected with 0.2ml of 1% calcium chloride(CaCl2) via the abdominal vein to relieve hyperkalemia,and ECGⅡ was again synchronously recorded.Results After injection of 0.2% KCl,ECG Ⅱ of the animals in experiment group showed that the heart rate was slowed down(P < 0.05),P-R interval was extended(P < 0.05),QRS was broadened and lowered(P < 0.05),T peak became higher(P < 0.05) as compared with that in control group.Two minutes after injection of 1% CaCl2,the ECG Ⅱ of the animals in experiment group recovered to normal status,and no significant difference was found between that of experiment group and control group.Conclusion The changes in ECG Ⅱ in toad model of myocardium hyperkalemia,produced by injection of 0.2% KCl,and then relieve the symptoms by injection of 1% CaCl2 via abdominal vein,is similar to that in mammals.Compared with other animal models,the hyperkalemia toad model is more convenient to be established with practical and stable result,and the cost is lower." @default.
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- W2249387683 date "2011-09-01" @default.
- W2249387683 modified "2023-09-24" @default.
- W2249387683 title "Reproduction of a hyperkalemia animal model" @default.
- W2249387683 hasPublicationYear "2011" @default.
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