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- W2249675487 abstract "8142 Background: Cancer of unknown primary site (CUP) accounts for approximately 5% of cancer diagnoses. Numerous chemotherapy strategies have been evaluated in this setting, but the prognosis remains poor. The combination of Gemcitabine (G) and Carboplatin (C) has a broad range of activity and acceptable tolerability making it a potential treatment of CUP. We report the final results of a multicenter prospective phase 2 trial of the GC combination in patients with CUP treated in 4 cancer centers across Adelaide, South Australia. Methods: ECOG performance status 0–2 patients with histologically confirmed metastatic carcinoma in which the primary site of cancer was not evident after prospectively designated investigations (including upper and lower GI endoscopy) were treated with G 1000 mg/m2 IV days 1 and 8, and C AUC 5 IV on day 8 every 3 weeks to a maximum of 9 cycles. The primary endpoints were response rate, toxicity, and quality of life. Other endpoints included time to progression and overall survival. Results: Median follow-up is 25 months (range 10 - 41). 50 (23 male, 27 female) patients were enrolled, with a median age of 69 yrs. (range 41–83). 46% were ≥ 70 yrs. Alopecia was minimal and significant nausea/vomiting was rare. The major toxicity and efficacy results are illustrated in the table below. Conclusions: The GC regimen has significant activity in CUP, with excellent tolerability and maintenance of Quality of Life, especially in this predominantly poor prognosis elderly population. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Eli Lilly" @default.
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- W2249675487 date "2005-06-01" @default.
- W2249675487 modified "2023-09-25" @default.
- W2249675487 title "Mulicenter phase II study of gemcitabine and carboplatin combination therapy for patients with metastatic carcinoma of unknown primary site: final results" @default.
- W2249675487 doi "https://doi.org/10.1200/jco.2005.23.16_suppl.8142" @default.
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