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- W2249771036 abstract "The aim of this research is to determine the role of leukemia inhibitory factor (LIF) in the decidualization response of the golden hamster uterus. The mechanism of LIF action in the implantation and decidualization process of mammals is unknown. LIF expression has been found to increase in several species during the implantation and decidualization process [1], but the mechanism controlling LIF expression during these events is not known. In the mouse, LIF appears to facilitate blastocyst implantation, which is associated with an estrogen surge [2]. There is no estrogen surge in the hamster, where progesterone, not estrogen, is the dominant hormone regulating embryo implantation and uterine decidualization [3]. The human is also a progesterone-dependent species and does not require estrogen for implantation [4,5]. Thus, we have tested the activity of LIF in the hamster, which is similar to the human in respect to the hormonal requirements for implantation, and this research is specifically designed to determine if LIF plays a role in the uterine decidualization response. The hypothesis is that treatment with LIF or an LIF antibody will affect the amount of uterine decidual tissue formed during the decidualization response following uterine traumatization in the progesterone-primed hamster." @default.
- W2249771036 created "2016-06-24" @default.
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- W2249771036 date "2005-04-22" @default.
- W2249771036 modified "2023-09-27" @default.
- W2249771036 title "LIF involvement in uterine decidualization and early implantation in the golden hamster" @default.
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