Matches in SemOpenAlex for { <https://semopenalex.org/work/W2250060833> ?p ?o ?g. }
- W2250060833 abstract "Here, we propose a new approach to defining nerve cell types in reaction to recent advances in single cell analysis. Among cells previously thought to be equivalent, considerable differences in global gene expression and biased tendencies among differing developmental fates have been demonstrated within multiple lineages. The model of classifying cells into distinct types thus has to be revised to account for this intrinsic variability. A cell type could be a group of cells that possess similar, but not necessarily identical properties, variable within a spectrum of epigenetic adjustments that permit its developmental path toward a specific function to be achieved. Thus, the definition of a cell type is becoming more similar to the definition of a species: sharing essential properties with other members of its group, but permitting a certain amount of deviation in aspects that do not seriously impact function. This approach accommodates, even embraces the spectrum of natural variation found in various cell populations and consequently avoids the fallacy of false equivalence. For example, developing neurons will react to their microenvironments with epigenetic changes resulting in slight changes in gene expression and morphology. Addressing the new questions implied here will have significant implications for developmental neurobiology." @default.
- W2250060833 created "2016-06-24" @default.
- W2250060833 creator A5046066980 @default.
- W2250060833 creator A5070067127 @default.
- W2250060833 creator A5086866710 @default.
- W2250060833 date "2015-12-16" @default.
- W2250060833 modified "2023-10-03" @default.
- W2250060833 title "Implications of Epigenetic Variability within a Cell Population for “Cell Type” Classification" @default.
- W2250060833 cites W1588361932 @default.
- W2250060833 cites W1604444942 @default.
- W2250060833 cites W1856781683 @default.
- W2250060833 cites W1923260397 @default.
- W2250060833 cites W1935339094 @default.
- W2250060833 cites W1964673742 @default.
- W2250060833 cites W1966279806 @default.
- W2250060833 cites W1966697925 @default.
- W2250060833 cites W1967324141 @default.
- W2250060833 cites W1968931043 @default.
- W2250060833 cites W1970789949 @default.
- W2250060833 cites W1971157309 @default.
- W2250060833 cites W1973727308 @default.
- W2250060833 cites W1979283544 @default.
- W2250060833 cites W1982236792 @default.
- W2250060833 cites W1982881824 @default.
- W2250060833 cites W1983281184 @default.
- W2250060833 cites W1984130135 @default.
- W2250060833 cites W1985995409 @default.
- W2250060833 cites W1987320425 @default.
- W2250060833 cites W1988405236 @default.
- W2250060833 cites W1991543373 @default.
- W2250060833 cites W1998663567 @default.
- W2250060833 cites W1999478182 @default.
- W2250060833 cites W2007639313 @default.
- W2250060833 cites W2010031978 @default.
- W2250060833 cites W2018466809 @default.
- W2250060833 cites W2019267922 @default.
- W2250060833 cites W2020893836 @default.
- W2250060833 cites W2021429824 @default.
- W2250060833 cites W2022522122 @default.
- W2250060833 cites W2023844789 @default.
- W2250060833 cites W2027638245 @default.
- W2250060833 cites W2044225191 @default.
- W2250060833 cites W2047918945 @default.
- W2250060833 cites W2050493077 @default.
- W2250060833 cites W2051658465 @default.
- W2250060833 cites W2053617989 @default.
- W2250060833 cites W2053716273 @default.
- W2250060833 cites W2055739897 @default.
- W2250060833 cites W2060199817 @default.
- W2250060833 cites W2060245619 @default.
- W2250060833 cites W2061078277 @default.
- W2250060833 cites W2063407989 @default.
- W2250060833 cites W2064537118 @default.
- W2250060833 cites W2064616746 @default.
- W2250060833 cites W2065103652 @default.
- W2250060833 cites W2065340354 @default.
- W2250060833 cites W2065511465 @default.
- W2250060833 cites W2068881679 @default.
- W2250060833 cites W2069089843 @default.
- W2250060833 cites W2069295116 @default.
- W2250060833 cites W2071010503 @default.
- W2250060833 cites W2072154498 @default.
- W2250060833 cites W2073453074 @default.
- W2250060833 cites W2073772517 @default.
- W2250060833 cites W2079054696 @default.
- W2250060833 cites W2080338559 @default.
- W2250060833 cites W2083839498 @default.
- W2250060833 cites W2084942072 @default.
- W2250060833 cites W2089172525 @default.
- W2250060833 cites W2097743364 @default.
- W2250060833 cites W2098432933 @default.
- W2250060833 cites W2098622547 @default.
- W2250060833 cites W2102212449 @default.
- W2250060833 cites W2110768394 @default.
- W2250060833 cites W2111607395 @default.
- W2250060833 cites W2111794549 @default.
- W2250060833 cites W2115736681 @default.
- W2250060833 cites W2117792884 @default.
- W2250060833 cites W2124376559 @default.
- W2250060833 cites W2126343030 @default.
- W2250060833 cites W2129428247 @default.
- W2250060833 cites W2131187320 @default.
- W2250060833 cites W2131263031 @default.
- W2250060833 cites W2131935275 @default.
- W2250060833 cites W2134555277 @default.
- W2250060833 cites W2135180965 @default.
- W2250060833 cites W2136941630 @default.
- W2250060833 cites W2137086195 @default.
- W2250060833 cites W2159082795 @default.
- W2250060833 cites W2161224111 @default.
- W2250060833 cites W2169327044 @default.
- W2250060833 cites W2171501288 @default.
- W2250060833 cites W2408912415 @default.
- W2250060833 cites W4241287911 @default.
- W2250060833 cites W4252280996 @default.
- W2250060833 doi "https://doi.org/10.3389/fnbeh.2015.00342" @default.
- W2250060833 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4679859" @default.
- W2250060833 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26733833" @default.
- W2250060833 hasPublicationYear "2015" @default.
- W2250060833 type Work @default.