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- W225020894 abstract "Objective To determine the relationship between advanced glycosylation end products(AGEs) and mild cognitive impairment in type 2 diabetic patients.Methods Based on the Mini-Mental State Examination(MMSE) score,type 2 diabetic patients were divided into two groups: one group with 30 cases of cognitive impairment and the other with 32 cases of non-cognitive impairment.30 normal participants served as the control group.AGEs was measured by ELISA in all subjects,also HbA1c,blood lipids,uric acid,fibrinogen,urinary albumin of 24 hours,and other biochemical indicators were measured in all subjects.Results The AGEs level of the cognitive impairment group was significantly higher than that of the non-cognitive impairment group(P0.05) and the control group(P0.01).MMSE score of patients with type 2 diabetes negatively correlated with age,duration of diabetes,HbA1c,body mass index,and serum levels of AGEs(r=-0.315,-0.276,-0.384,-0.384,-0.282).Conclusions Increased AGEs may be an important risk factor for cognitive impairment in type 2 diabetic patients.AGEs may be involved in the pathogenesis of diabetic encephalopathy." @default.
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- W225020894 date "2009-01-01" @default.
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- W225020894 title "Correlation between mild cognitive impairment and advanced glycosylation end product level in type 2 diabetic patients." @default.
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