FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2251145129> ?p ?o ?g. }

• W2251145129 endingPage "232" @default.
• W2251145129 startingPage "221" @default.
• W2251145129 abstract "Muscle glucose storage and muscle glycogen synthase (gys1) defects have been associated with insulin resistance. As there are multiple mechanisms for insulin resistance, the specific role of glucose storage defects is not clear. The aim of this study was to examine the effects of muscle-specific gys1 deletion on glucose metabolism and exercise capacity. Tamoxifen inducible and muscle specific gys-1 KO mice were generated using the Cre/loxP system. Mice were subjected to glucose tolerance tests, euglycemic/hyperinsulinemic clamps and exercise tests. gys1-KO mice showed ≥85% reduction in muscle gys1 mRNA and protein concentrations, 70% reduction in muscle glycogen levels, postprandial hyperglycaemia and hyperinsulinaemia and impaired glucose tolerance. Under insulin-stimulated conditions, gys1-KO mice displayed reduced glucose turnover and muscle glucose uptake, indicative of peripheral insulin resistance, as well as increased plasma and muscle lactate levels and reductions in muscle hexokinase II levels. gys1-KO mice also exhibited markedly reduced exercise and endurance capacity. Thus, muscle-specific gys1 deletion in adult mice results in glucose intolerance due to insulin resistance and reduced muscle glucose uptake as well as impaired exercise and endurance capacity. This study demonstrates why the body prioritises muscle glycogen storage over liver glycogen storage despite the critical role of the liver in supplying glucose to the brain in the fasting state and shows that glycogen deficiency results in impaired glucose metabolism and reduced exercise capacity." @default.
• W2251145129 created "2016-06-24" @default.
• W2251145129 creator A5013046723 @default.
• W2251145129 creator A5022967152 @default.
• W2251145129 creator A5027789643 @default.
• W2251145129 creator A5030146005 @default.
• W2251145129 creator A5031358282 @default.
• W2251145129 creator A5043449767 @default.
• W2251145129 creator A5043560888 @default.
• W2251145129 creator A5053988365 @default.
• W2251145129 creator A5076079712 @default.
• W2251145129 creator A5078364062 @default.
• W2251145129 creator A5080952866 @default.
• W2251145129 creator A5082379375 @default.
• W2251145129 creator A5087490162 @default.
• W2251145129 date "2016-03-01" @default.
• W2251145129 modified "2023-10-01" @default.
• W2251145129 title "Impaired glucose metabolism and exercise capacity with muscle-specific glycogen synthase 1 (gys1) deletion in adult mice" @default.
• W2251145129 cites W1533103223 @default.
• W2251145129 cites W1757757462 @default.
• W2251145129 cites W1972639568 @default.
• W2251145129 cites W1977322694 @default.
• W2251145129 cites W1979208993 @default.
• W2251145129 cites W1995375315 @default.
• W2251145129 cites W1999830994 @default.
• W2251145129 cites W2003817405 @default.
• W2251145129 cites W2006984906 @default.
• W2251145129 cites W2009509125 @default.
• W2251145129 cites W2012413019 @default.
• W2251145129 cites W2012830485 @default.
• W2251145129 cites W2019612671 @default.
• W2251145129 cites W2021531219 @default.
• W2251145129 cites W2023027042 @default.
• W2251145129 cites W2032786086 @default.
• W2251145129 cites W2033524876 @default.
• W2251145129 cites W2033696586 @default.
• W2251145129 cites W2036060364 @default.
• W2251145129 cites W2041032782 @default.
• W2251145129 cites W2042698420 @default.
• W2251145129 cites W2043137697 @default.
• W2251145129 cites W2043648447 @default.
• W2251145129 cites W2049107834 @default.
• W2251145129 cites W2051028541 @default.
• W2251145129 cites W2057127647 @default.
• W2251145129 cites W2060380315 @default.
• W2251145129 cites W2067901605 @default.
• W2251145129 cites W2072656195 @default.
• W2251145129 cites W2073225243 @default.
• W2251145129 cites W2079717789 @default.
• W2251145129 cites W2083370407 @default.
• W2251145129 cites W2098390182 @default.
• W2251145129 cites W2106043736 @default.
• W2251145129 cites W2107219840 @default.
• W2251145129 cites W2109297349 @default.
• W2251145129 cites W2109965669 @default.
• W2251145129 cites W2114647345 @default.
• W2251145129 cites W2116270367 @default.
• W2251145129 cites W2119150441 @default.
• W2251145129 cites W2122953585 @default.
• W2251145129 cites W2125578565 @default.
• W2251145129 cites W2126835430 @default.
• W2251145129 cites W2129700082 @default.
• W2251145129 cites W2129971834 @default.
• W2251145129 cites W2131767711 @default.
• W2251145129 cites W2131771191 @default.
• W2251145129 cites W2132136543 @default.
• W2251145129 cites W2135190643 @default.
• W2251145129 cites W2144496944 @default.
• W2251145129 cites W2144794300 @default.
• W2251145129 cites W2145355738 @default.
• W2251145129 cites W2148769969 @default.
• W2251145129 cites W2150470419 @default.
• W2251145129 cites W2153091256 @default.
• W2251145129 cites W2155243614 @default.
• W2251145129 cites W2159554058 @default.
• W2251145129 cites W2164760719 @default.
• W2251145129 cites W2166542068 @default.
• W2251145129 cites W2169132058 @default.
• W2251145129 cites W2169401893 @default.
• W2251145129 cites W2169632698 @default.
• W2251145129 cites W2170025977 @default.
• W2251145129 cites W2170869159 @default.
• W2251145129 cites W2171109639 @default.
• W2251145129 cites W2171814772 @default.
• W2251145129 cites W2341717561 @default.
• W2251145129 cites W2341913913 @default.
• W2251145129 cites W3023039152 @default.
• W2251145129 doi "https://doi.org/10.1016/j.molmet.2016.01.004" @default.
• W2251145129 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4770268" @default.
• W2251145129 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26977394" @default.
• W2251145129 hasPublicationYear "2016" @default.
• W2251145129 type Work @default.
• W2251145129 sameAs 2251145129 @default.
• W2251145129 citedByCount "41" @default.
• W2251145129 countsByYear W22511451292016 @default.
• W2251145129 countsByYear W22511451292017 @default.
• W2251145129 countsByYear W22511451292018 @default.
• W2251145129 countsByYear W22511451292019 @default.

• next