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• W2251297188 endingPage "pyv089" @default.
• W2251297188 startingPage "pyv089" @default.
• W2251297188 abstract "Brain-derived neurotrophic factor (BDNF) deficiency confers vulnerability to stress, but the mechanisms are unclear. BDNF(+/-) mice exhibit behavioral, physiological, and neurochemical changes following low-level stress that are hallmarks of major depression. After immune challenge, neuroinflammation-induced changes in tryptophan metabolism along the kynurenine pathway mediate depressive-like behaviors.We hypothesized that BDNF(+/-) mice would be more susceptible to stress-induced neuroinflammation and kynurenine metabolism, so BDNF(+/-) or wild-type littermate mice were subject to repeated unpredictable mild stress. Proinflammatory cytokine expression and kynurenine metabolites were measured.Unpredictable mild stress did not induce neuroinflammation. However, only wild-type mice produced the neuroprotective factors interleukin-10 and kynurenic acid in response to repeated unpredictable mild stress. In BDNF(+/-) mice, kynurenine was metabolized preferentially to the neurotoxic intermediate 3-hydroxykynurenine following repeated unpredictable mild stress.Our data suggest that BDNF may modulate kynurenine pathway metabolism during stress and provide a novel molecular mechanism of vulnerability and resilience to the development of stress-precipitated psychiatric disorders." @default.
• W2251297188 created "2016-06-24" @default.
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• W2251297188 date "2015-08-01" @default.
• W2251297188 modified "2023-10-16" @default.
• W2251297188 title "Low-Level Stress Induces Production of Neuroprotective Factors in Wild-Type but Not BDNF^+/-Mice: Interleukin-10 and Kynurenic Acid" @default.
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• W2251297188 doi "https://doi.org/10.1093/ijnp/pyv089" @default.
• W2251297188 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4815464" @default.
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• W2251297188 hasPublicationYear "2015" @default.
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