Matches in SemOpenAlex for { <https://semopenalex.org/work/W2251641> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2251641 endingPage "52" @default.
- W2251641 startingPage "148" @default.
- W2251641 abstract "This study was conducted to evaluate the effectiveness and safety of topiramate as add-on therapy for treatment-resistant bipolar disorder.Twenty-one DSM-IV bipolar patients, considered resistant to treatment with lithium, carbamazepine or valproate, gave informed consent to receive increasing doses of the novel anticonvulsant topiramate as adjunctive therapy for their manic (n= 9), depressive (n= 6), hypomanic (n= 3), mixed (n= 2) or schizoaffective manic (n= 1) symptoms. The dosage of other mood stabilizer drugs remained unchanged throughout the 6-week follow-up. Outcome measures included the YMRS, HDRS-17, and CGI scales. Fifteen out of 21 patients completed the 6-week follow-up.Six patients (40% of completers, 29% by intention-to-treat) were considered responders to topiramate (> 50% reduction in YMRS or HDRS-17 and a decrease of 2 points in CGI). The drug was less effective in intially depressed patients. Topiramate was well tolerated and only one patient discontinued due to side-effects. The most common adverse effect was paresthesia (n= 2). Ten patients experienced moderate weight loss during the follow-up. The mean topiramate dose at endpoint was 158 mg/day.These preliminary results suggest that topiramate may be a useful therapy for bipolar disorders, with promising results even in the most treatment-refractory patients." @default.
- W2251641 created "2016-06-24" @default.
- W2251641 creator A5006921582 @default.
- W2251641 creator A5029980554 @default.
- W2251641 creator A5058900206 @default.
- W2251641 creator A5061926369 @default.
- W2251641 creator A5066842349 @default.
- W2251641 creator A5070762290 @default.
- W2251641 creator A5071204494 @default.
- W2251641 date "2001-06-20" @default.
- W2251641 modified "2023-09-27" @default.
- W2251641 title "[Effectiveness and safety of topiramate in treatment-resistant bipolar disorder]." @default.
- W2251641 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11412488" @default.
- W2251641 hasPublicationYear "2001" @default.
- W2251641 type Work @default.
- W2251641 sameAs 2251641 @default.
- W2251641 citedByCount "4" @default.
- W2251641 countsByYear W22516412018 @default.
- W2251641 crossrefType "journal-article" @default.
- W2251641 hasAuthorship W2251641A5006921582 @default.
- W2251641 hasAuthorship W2251641A5029980554 @default.
- W2251641 hasAuthorship W2251641A5058900206 @default.
- W2251641 hasAuthorship W2251641A5061926369 @default.
- W2251641 hasAuthorship W2251641A5066842349 @default.
- W2251641 hasAuthorship W2251641A5070762290 @default.
- W2251641 hasAuthorship W2251641A5071204494 @default.
- W2251641 hasConcept C118552586 @default.
- W2251641 hasConcept C121332964 @default.
- W2251641 hasConcept C126322002 @default.
- W2251641 hasConcept C142424586 @default.
- W2251641 hasConcept C15744967 @default.
- W2251641 hasConcept C197934379 @default.
- W2251641 hasConcept C2775858608 @default.
- W2251641 hasConcept C2776174506 @default.
- W2251641 hasConcept C2776809841 @default.
- W2251641 hasConcept C2777683783 @default.
- W2251641 hasConcept C2778186239 @default.
- W2251641 hasConcept C2778541603 @default.
- W2251641 hasConcept C2778609679 @default.
- W2251641 hasConcept C2779253243 @default.
- W2251641 hasConcept C2780550438 @default.
- W2251641 hasConcept C42219234 @default.
- W2251641 hasConcept C71924100 @default.
- W2251641 hasConcept C87355193 @default.
- W2251641 hasConceptScore W2251641C118552586 @default.
- W2251641 hasConceptScore W2251641C121332964 @default.
- W2251641 hasConceptScore W2251641C126322002 @default.
- W2251641 hasConceptScore W2251641C142424586 @default.
- W2251641 hasConceptScore W2251641C15744967 @default.
- W2251641 hasConceptScore W2251641C197934379 @default.
- W2251641 hasConceptScore W2251641C2775858608 @default.
- W2251641 hasConceptScore W2251641C2776174506 @default.
- W2251641 hasConceptScore W2251641C2776809841 @default.
- W2251641 hasConceptScore W2251641C2777683783 @default.
- W2251641 hasConceptScore W2251641C2778186239 @default.
- W2251641 hasConceptScore W2251641C2778541603 @default.
- W2251641 hasConceptScore W2251641C2778609679 @default.
- W2251641 hasConceptScore W2251641C2779253243 @default.
- W2251641 hasConceptScore W2251641C2780550438 @default.
- W2251641 hasConceptScore W2251641C42219234 @default.
- W2251641 hasConceptScore W2251641C71924100 @default.
- W2251641 hasConceptScore W2251641C87355193 @default.
- W2251641 hasIssue "3" @default.
- W2251641 hasLocation W22516411 @default.
- W2251641 hasOpenAccess W2251641 @default.
- W2251641 hasPrimaryLocation W22516411 @default.
- W2251641 hasRelatedWork W1499140868 @default.
- W2251641 hasRelatedWork W1965502821 @default.
- W2251641 hasRelatedWork W197572465 @default.
- W2251641 hasRelatedWork W2011991065 @default.
- W2251641 hasRelatedWork W2090194189 @default.
- W2251641 hasRelatedWork W2123791787 @default.
- W2251641 hasRelatedWork W2154790483 @default.
- W2251641 hasRelatedWork W2430271442 @default.
- W2251641 hasRelatedWork W2480292 @default.
- W2251641 hasRelatedWork W2886780391 @default.
- W2251641 hasVolume "29" @default.
- W2251641 isParatext "false" @default.
- W2251641 isRetracted "false" @default.
- W2251641 magId "2251641" @default.
- W2251641 workType "article" @default.