Matches in SemOpenAlex for { <https://semopenalex.org/work/W2251819281> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2251819281 abstract "Neuropathic pain is of serious clinical concern and only about half of patients achieve partial relief with currently-available treatments, so it is critical to find new drugs for this condition. Recently, the cellsurface trafficking of pain-related receptors has been suggested as an important mechanism underlying persistent neuropathic pain. Here, we used the short peptide GluA2-3y, which specifically inhibits the GluA2-dependent endocytosis of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors, and tested its anti-nociceptive effect in the periaqueductal grey (PAG) of intact rats and rats with neuropathic pain. Intra-PAG injection of 0.15, 1.5, 7.5, and 15 pmol of GluA2-3y induced dose-dependent increases in hindpaw withdrawal latencies to noxious thermal and mechanical stimuli in intact rats, suggesting that GluA2 cell-surface trafficking in the PAG is involved in pain modulation. Furthermore, GluA2-3y had much stronger anti-nociceptive effects in rats with neuropathic pain induced by sciatic nerve ligation. Interestingly, the intra-PAG injection of 15 pmol GluA2-3y had an analgesic effect similar to 10 μg (35 nmol) morphine in rats with neuropathic pain. Taken together, our results suggested that GluA2 trafficking in the PAG plays a critical role in pain modulation, and inhibiting GluA2 endocytosis with GluA2-3y has potent analgesic effects in rats with neuropathic pain. These findings strongly support the recent hypothesis that targeting receptor trafficking could be a new strategy for the treatment of neuropathic pain." @default.
- W2251819281 created "2016-06-24" @default.
- W2251819281 creator A5011838198 @default.
- W2251819281 creator A5031244438 @default.
- W2251819281 creator A5052627018 @default.
- W2251819281 creator A5077870973 @default.
- W2251819281 date "2015-08-06" @default.
- W2251819281 modified "2023-09-29" @default.
- W2251819281 title "Pharmacologically inhibiting GluR2 internalization alleviates neuropathic pain" @default.
- W2251819281 cites W1973081422 @default.
- W2251819281 cites W1977077283 @default.
- W2251819281 cites W1989644542 @default.
- W2251819281 cites W1994562191 @default.
- W2251819281 cites W1997001171 @default.
- W2251819281 cites W2016474170 @default.
- W2251819281 cites W2037043198 @default.
- W2251819281 cites W2040851253 @default.
- W2251819281 cites W2050247484 @default.
- W2251819281 cites W2058020736 @default.
- W2251819281 cites W2062700118 @default.
- W2251819281 cites W2064279886 @default.
- W2251819281 cites W2067988122 @default.
- W2251819281 cites W2074385487 @default.
- W2251819281 cites W2088600148 @default.
- W2251819281 cites W2094310013 @default.
- W2251819281 cites W2102148913 @default.
- W2251819281 cites W2138499080 @default.
- W2251819281 cites W2169040543 @default.
- W2251819281 cites W4239234644 @default.
- W2251819281 doi "https://doi.org/10.1007/s12264-015-1556-2" @default.
- W2251819281 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5563682" @default.
- W2251819281 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26248656" @default.
- W2251819281 hasPublicationYear "2015" @default.
- W2251819281 type Work @default.
- W2251819281 sameAs 2251819281 @default.
- W2251819281 citedByCount "10" @default.
- W2251819281 countsByYear W22518192812016 @default.
- W2251819281 countsByYear W22518192812017 @default.
- W2251819281 countsByYear W22518192812018 @default.
- W2251819281 countsByYear W22518192812020 @default.
- W2251819281 countsByYear W22518192812021 @default.
- W2251819281 countsByYear W22518192812023 @default.
- W2251819281 crossrefType "journal-article" @default.
- W2251819281 hasAuthorship W2251819281A5011838198 @default.
- W2251819281 hasAuthorship W2251819281A5031244438 @default.
- W2251819281 hasAuthorship W2251819281A5052627018 @default.
- W2251819281 hasAuthorship W2251819281A5077870973 @default.
- W2251819281 hasBestOaLocation W22518192812 @default.
- W2251819281 hasConcept C104211972 @default.
- W2251819281 hasConcept C126322002 @default.
- W2251819281 hasConcept C15490471 @default.
- W2251819281 hasConcept C15744967 @default.
- W2251819281 hasConcept C169760540 @default.
- W2251819281 hasConcept C170493617 @default.
- W2251819281 hasConcept C2777107010 @default.
- W2251819281 hasConcept C2780820201 @default.
- W2251819281 hasConcept C42219234 @default.
- W2251819281 hasConcept C71924100 @default.
- W2251819281 hasConcept C98274493 @default.
- W2251819281 hasConceptScore W2251819281C104211972 @default.
- W2251819281 hasConceptScore W2251819281C126322002 @default.
- W2251819281 hasConceptScore W2251819281C15490471 @default.
- W2251819281 hasConceptScore W2251819281C15744967 @default.
- W2251819281 hasConceptScore W2251819281C169760540 @default.
- W2251819281 hasConceptScore W2251819281C170493617 @default.
- W2251819281 hasConceptScore W2251819281C2777107010 @default.
- W2251819281 hasConceptScore W2251819281C2780820201 @default.
- W2251819281 hasConceptScore W2251819281C42219234 @default.
- W2251819281 hasConceptScore W2251819281C71924100 @default.
- W2251819281 hasConceptScore W2251819281C98274493 @default.
- W2251819281 hasLocation W22518192811 @default.
- W2251819281 hasLocation W22518192812 @default.
- W2251819281 hasLocation W22518192813 @default.
- W2251819281 hasLocation W22518192814 @default.
- W2251819281 hasOpenAccess W2251819281 @default.
- W2251819281 hasPrimaryLocation W22518192811 @default.
- W2251819281 hasRelatedWork W1525533476 @default.
- W2251819281 hasRelatedWork W1594786713 @default.
- W2251819281 hasRelatedWork W1596701898 @default.
- W2251819281 hasRelatedWork W1971935688 @default.
- W2251819281 hasRelatedWork W2010290939 @default.
- W2251819281 hasRelatedWork W2028312436 @default.
- W2251819281 hasRelatedWork W203475150 @default.
- W2251819281 hasRelatedWork W2034787581 @default.
- W2251819281 hasRelatedWork W2067297616 @default.
- W2251819281 hasRelatedWork W2079790110 @default.
- W2251819281 hasRelatedWork W2081308078 @default.
- W2251819281 hasRelatedWork W2146272796 @default.
- W2251819281 hasRelatedWork W2262873879 @default.
- W2251819281 hasRelatedWork W2462104211 @default.
- W2251819281 hasRelatedWork W2528957096 @default.
- W2251819281 hasRelatedWork W2972094380 @default.
- W2251819281 hasRelatedWork W2991131684 @default.
- W2251819281 hasRelatedWork W3029330932 @default.
- W2251819281 hasRelatedWork W3206469730 @default.
- W2251819281 hasRelatedWork W917092203 @default.
- W2251819281 isParatext "false" @default.
- W2251819281 isRetracted "false" @default.
- W2251819281 magId "2251819281" @default.
- W2251819281 workType "article" @default.