FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2252616141> ?p ?o ?g. }

• W2252616141 endingPage "e0147170" @default.
• W2252616141 startingPage "e0147170" @default.
• W2252616141 abstract "The Acute Respiratory Distress Syndrome (ARDS) is a devastating clinical condition that is associated with a 30–40% risk of death, and significant long term morbidity for those who survive. Mesenchymal stromal cells (MSC) have emerged as a potential novel treatment as in pre-clinical models they have been shown to modulate inflammation (a major pathophysiological hallmark of ARDS) while enhancing bacterial clearance and reducing organ injury and death. A systematic search of MEDLINE, EMBASE, BIOSIS and Web of Science was performed to identify pre-clinical studies that examined the efficacy MSCs as compared to diseased controls for the treatment of Acute Lung Injury (ALI) (the pre-clinical correlate of human ARDS) on mortality, a clinically relevant outcome. We assessed study quality and pooled results using random effect meta-analysis. A total of 54 publications met our inclusion criteria of which 17 (21 experiments) reported mortality and were included in the meta-analysis. Treatment with MSCs, as compared to controls, significantly decreased the overall odds of death in animals with ALI (Odds Ratio 0.24, 95% Confidence Interval 0.18–0.34, I2 8%). Efficacy was maintained across different types of animal models and means of ALI induction; MSC origin, source, route of administration and preparation; and the clinical relevance of the model (timing of MSC administration, administration of fluids and or antibiotics). Reporting of standard MSC characterization for experiments that used human MSCs and risks of bias was generally poor, and although not statistically significant, a funnel plot analysis for overall mortality suggested the presence of publication bias. The results from our meta-analysis support that MSCs substantially reduce the odds of death in animal models of ALI but important reporting elements were sub optimal and limit the strength of our conclusions." @default.
• W2252616141 created "2016-06-24" @default.
• W2252616141 creator A5007813511 @default.
• W2252616141 creator A5009089580 @default.
• W2252616141 creator A5020594380 @default.
• W2252616141 creator A5022700654 @default.
• W2252616141 creator A5042174892 @default.
• W2252616141 creator A5052134087 @default.
• W2252616141 creator A5052927010 @default.
• W2252616141 creator A5054403907 @default.
• W2252616141 creator A5068353058 @default.
• W2252616141 creator A5069735529 @default.
• W2252616141 creator A5069849817 @default.
• W2252616141 creator A5070604004 @default.
• W2252616141 creator A5071896609 @default.
• W2252616141 creator A5073098365 @default.
• W2252616141 creator A5084706902 @default.
• W2252616141 creator A5085718584 @default.
• W2252616141 date "2016-01-28" @default.
• W2252616141 modified "2023-10-03" @default.
• W2252616141 title "Efficacy of Mesenchymal Stromal Cell Therapy for Acute Lung Injury in Preclinical Animal Models: A Systematic Review" @default.
• W2252616141 cites W117882811 @default.
• W2252616141 cites W1480729244 @default.
• W2252616141 cites W1964493140 @default.
• W2252616141 cites W1965104586 @default.
• W2252616141 cites W1977022191 @default.
• W2252616141 cites W1983175587 @default.
• W2252616141 cites W1986215651 @default.
• W2252616141 cites W1987609279 @default.
• W2252616141 cites W1991209345 @default.
• W2252616141 cites W1994788053 @default.
• W2252616141 cites W1998194680 @default.
• W2252616141 cites W1998861298 @default.
• W2252616141 cites W2000584719 @default.
• W2252616141 cites W2003247605 @default.
• W2252616141 cites W2005501262 @default.
• W2252616141 cites W2007104379 @default.
• W2252616141 cites W2010967955 @default.
• W2252616141 cites W2016395601 @default.
• W2252616141 cites W2020889177 @default.
• W2252616141 cites W2025371271 @default.
• W2252616141 cites W2038693293 @default.
• W2252616141 cites W2043031595 @default.
• W2252616141 cites W2046005886 @default.
• W2252616141 cites W2050034605 @default.
• W2252616141 cites W2055289656 @default.
• W2252616141 cites W2055767345 @default.
• W2252616141 cites W2062605932 @default.
• W2252616141 cites W2065842651 @default.
• W2252616141 cites W2067800417 @default.
• W2252616141 cites W2069056995 @default.
• W2252616141 cites W2072111229 @default.
• W2252616141 cites W2075266563 @default.
• W2252616141 cites W2078142671 @default.
• W2252616141 cites W2082728447 @default.
• W2252616141 cites W2085030928 @default.
• W2252616141 cites W2089214984 @default.
• W2252616141 cites W2092892225 @default.
• W2252616141 cites W2093004262 @default.
• W2252616141 cites W2094024512 @default.
• W2252616141 cites W2104198623 @default.
• W2252616141 cites W2106620537 @default.
• W2252616141 cites W2111727066 @default.
• W2252616141 cites W2115788075 @default.
• W2252616141 cites W2118149275 @default.
• W2252616141 cites W2121190453 @default.
• W2252616141 cites W2124056092 @default.
• W2252616141 cites W2130323675 @default.
• W2252616141 cites W2134338262 @default.
• W2252616141 cites W2138589210 @default.
• W2252616141 cites W2142395330 @default.
• W2252616141 cites W2152652033 @default.
• W2252616141 cites W2155254073 @default.
• W2252616141 cites W2156100542 @default.
• W2252616141 cites W2159400425 @default.
• W2252616141 cites W2161006376 @default.
• W2252616141 cites W2165440991 @default.
• W2252616141 cites W2165537330 @default.
• W2252616141 cites W2166019746 @default.
• W2252616141 cites W2168000701 @default.
• W2252616141 cites W2169220893 @default.
• W2252616141 cites W2169299508 @default.
• W2252616141 cites W2265488122 @default.
• W2252616141 cites W2314787815 @default.
• W2252616141 cites W2338234533 @default.
• W2252616141 cites W2353867594 @default.
• W2252616141 cites W2407229623 @default.
• W2252616141 cites W2413547191 @default.
• W2252616141 cites W2416953314 @default.
• W2252616141 cites W30093018 @default.
• W2252616141 doi "https://doi.org/10.1371/journal.pone.0147170" @default.
• W2252616141 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4731557" @default.
• W2252616141 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26821255" @default.
• W2252616141 hasPublicationYear "2016" @default.
• W2252616141 type Work @default.
• W2252616141 sameAs 2252616141 @default.
• W2252616141 citedByCount "98" @default.
• W2252616141 countsByYear W22526161412016 @default.

• next