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- W2252783105 abstract "Maintaining DNA integrity is vital for all cells and organisms. Defective DNA repair may contribute to neurological disorders, including Alzheimer's disease (AD). We found reduced levels of BRCA1, but not of other DNA repair factors, in the brains of AD patients and human amyloid precursor protein (hAPP) transgenic mice. Amyloid-β oligomers reduced BRCA1 levels in primary neuronal cultures. In wild-type mice, knocking down neuronal BRCA1 in the dentate gyrus caused increased DNA double-strand breaks, neuronal shrinkage, synaptic plasticity impairments, and learning and memory deficits, but not apoptosis. Low levels of hAPP/Amyloid-β overexpression exacerbated these effects. Physiological neuronal activation increased BRCA1 levels, whereas stimulating predominantly extrasynaptic N-methyl-D-aspartate receptors promoted the proteasomal degradation of BRCA1. We conclude that BRCA1 is regulated by neuronal activity, protects the neuronal genome, and critically supports neuronal integrity and cognitive functions. Pathological accumulation of Aβ depletes neuronal BRCA1, which may contribute to cognitive deficits in AD." @default.
- W2252783105 created "2016-06-24" @default.
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- W2252783105 date "2015-11-30" @default.
- W2252783105 modified "2023-10-06" @default.
- W2252783105 title "DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice" @default.
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- W2252783105 cites W1906859819 @default.
- W2252783105 cites W1967061503 @default.
- W2252783105 cites W1967917932 @default.
- W2252783105 cites W1968692604 @default.
- W2252783105 cites W1970910654 @default.
- W2252783105 cites W1973309606 @default.
- W2252783105 cites W1974682687 @default.
- W2252783105 cites W1981452104 @default.
- W2252783105 cites W1981457167 @default.
- W2252783105 cites W1981504932 @default.
- W2252783105 cites W1982373527 @default.
- W2252783105 cites W1985786559 @default.
- W2252783105 cites W1989247107 @default.
- W2252783105 cites W1991625887 @default.
- W2252783105 cites W1994435157 @default.
- W2252783105 cites W1997313092 @default.
- W2252783105 cites W1997396304 @default.
- W2252783105 cites W2000196896 @default.
- W2252783105 cites W2002181764 @default.
- W2252783105 cites W2003320905 @default.
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- W2252783105 cites W2034485370 @default.
- W2252783105 cites W2035466313 @default.
- W2252783105 cites W2037321375 @default.
- W2252783105 cites W2039220621 @default.
- W2252783105 cites W2042154782 @default.
- W2252783105 cites W2049725307 @default.
- W2252783105 cites W2056079743 @default.
- W2252783105 cites W2057815562 @default.
- W2252783105 cites W2060792241 @default.
- W2252783105 cites W2061095991 @default.
- W2252783105 cites W2062605351 @default.
- W2252783105 cites W2069281265 @default.
- W2252783105 cites W2073845000 @default.
- W2252783105 cites W2080053685 @default.
- W2252783105 cites W2081070804 @default.
- W2252783105 cites W2088267321 @default.
- W2252783105 cites W2088470456 @default.
- W2252783105 cites W2092764200 @default.
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- W2252783105 cites W2115017507 @default.
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- W2252783105 cites W2146507524 @default.
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- W2252783105 cites W2154368046 @default.
- W2252783105 cites W2170687235 @default.
- W2252783105 cites W2170822456 @default.
- W2252783105 cites W2172209713 @default.
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- W2252783105 doi "https://doi.org/10.1038/ncomms9897" @default.
- W2252783105 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4674776" @default.
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- W2252783105 hasPublicationYear "2015" @default.
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