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- W2252826849 abstract "An efficient and scalable synthesis of an antidiabetic drug, tofogliflozin (1), which was identified as a highly selective sodium glucose cotransporter 2 (SGLT2) inhibitor, is described. A key factor in the synthesis of 1 was the selection of the purpose-designed protecting group, which plays a strategic role in protection, chemoselective activation, and crystalline purification. The developed and optimized method made it possible to prepare 1 on a multidecagram scale without any column chromatography." @default.
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- W2252826849 date "2016-02-19" @default.
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- W2252826849 title "Development of a Scalable Synthesis of Tofogliflozin" @default.
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- W2252826849 doi "https://doi.org/10.1021/acs.joc.5b02734" @default.
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